评估辐射敏感性指数和12种趋化因子基因表达特征以用于CLIA实验室的临床应用。
Evaluating the Radiation Sensitivity Index and 12-Chemokine Gene Expression Signature for Clinical Use in a CLIA Laboratory.
作者信息
Berglund Anders E, Puskas John, Yoder Sean J, Smith Andrew T, Marchion Douglas C, Qin Dahui, Mulé James J, Torres-Roca Javier F, Eschrich Steven A
机构信息
Department of Biostatistics and Bioinformatics, Moffitt Cancer Center & Research Institute, Tampa, Florida.
Department of Quantitative Health Sciences, Mayo Clinic Florida, Jacksonville, Florida.
出版信息
Cancer Res Commun. 2025 Mar 1;5(3):389-397. doi: 10.1158/2767-9764.CRC-24-0534.
The RSI and 12CK GES are two GESs that predict tumor radiation sensitivity or the presence of tertiary lymphoid structures in tumors, respectively. These GESs were assessed within the CLIA process for future clinical use. We established proficiency, reproducibility, and reliability characteristics for both signatures in a controlled setting, indicating these GESs are suitable for validation within future clinical trials.
相对强弱指数（RSI）和12CK基因表达谱（GES）是分别预测肿瘤放射敏感性或肿瘤中三级淋巴结构存在情况的两种基因表达谱。这些基因表达谱在临床实验室改进修正案（CLIA）流程中进行评估，以备将来临床使用。我们在可控环境中确定了这两种特征谱的熟练度、可重复性和可靠性特征，表明这些基因表达谱适用于未来临床试验中的验证。
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