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贝佐替凡开启VHL病相关肿瘤管理的新时代

A New Era of Management of Von Hippel-Lindau Disease-Associated Tumors With Belzutifan.

作者信息

Niccum Haag Heather

机构信息

Heather Niccum Haag.

出版信息

Clin J Oncol Nurs. 2025 Jan 17;29(1):25-29. doi: 10.1188/25.CJON.25-29.

Abstract

Belzutifan is a first-in-class hypoxia-inducible factor 2 alpha, or HIF-2 alpha, inhibitor drug for the treatment of hemangioblastomas of the central nervous system and pancreatic neuroendocrine tumors in adults with von Hipp.

摘要

贝佐蒂凡(Belzutifan)是一种一流的缺氧诱导因子2α(HIF-2α)抑制剂药物,用于治疗患有冯·希佩尔-林道(von Hipp)病的成人中枢神经系统血管母细胞瘤和胰腺神经内分泌肿瘤。

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本文引用的文献

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Special FDA designations for drug development: orphan, fast track, accelerated approval, priority review, and breakthrough therapy.
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Outcomes of and indications for renal transplantation in patients with von Hippel Lindau disease.
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Understanding the Impact of Belzutifan on Treatment Strategies for Patients with VHL.
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Belzutifan for Renal Cell Carcinoma in von Hippel-Lindau Disease.
N Engl J Med. 2021 Nov 25;385(22):2036-2046. doi: 10.1056/NEJMoa2103425.
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Hemangioblastoma diagnosis and surveillance in von Hippel-Lindau disease: a consensus statement.
J Neurosurg. 2021 Oct 1;136(6):1511-1516. doi: 10.3171/2021.3.JNS204203. Print 2022 Jun 1.
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Pheochromocytomas and paragangliomas in von Hippel-Lindau disease: not a needle in a haystack.
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