Lee Mon-Chien, Hsu Yi-Ju, Yang Hung-Jen, Huang Chi-Chang
Graduate Institute of Sports Science, National Taiwan Sport University, Taoyuan City 333325, Taiwan.
Center for General Education, Taipei Medical University, Taipei 110301, Taiwan.
Nutrients. 2025 Jan 27;17(3):463. doi: 10.3390/nu17030463.
: As individuals age, there is a gradual loss of muscle mass and strength, which not only impairs physical functionality but also heightens the risk of falls and diminishes independence among older adults. Probiotics have emerged as a focus of recent research due to their potential role in enhancing muscle health via the gut-muscle axis. This study evaluates the effects of live and heat-treated PS23 (PS23) supplementation on muscle strength and mass in the elderly. This study recruited 119 participants, aged 65-85 years, and randomly assigned them to receive a placebo (0 × 10 CFU/day), L-PS23 (live PS23, 2 × 10 CFU/day), or HT-PS23 (heat-treated PS23, 2 × 10 cells/day) for a duration of 12 weeks. Assessments of blood pressure, body composition, muscle strength, functional physical fitness, and biochemical parameters were conducted at baseline, 6 weeks, and 12 weeks. Among the 100 subjects who completed the trial, supplementation with both L-PS23 and HT-PS23 significantly enhanced lower limb muscle strength and endurance compared to the placebo ( < 0.05), although no significant differences were observed in muscle mass or upper limb muscle strength across the groups. Additionally, while most muscle anabolism-related markers showed no significant changes, both supplements effectively decreased inflammatory markers related to aging-C-reactive protein (CRP: L-PS23, = 0.016; HT-PS23, = 0.013) and interleukin-6 (IL-6: L-PS23, = 0.003; HT-PS23, < 0.001)-and increased interleukin-10 levels (L-PS23, = 0.014; HT-PS23, = 0.005). Notably, only the HT-PS23 group demonstrated a significant increase in testosterone levels ( = 0.029). 12 weeks of supplementation with L-PS23 and HT-PS23 improved lower limb muscle strength and endurance but did not significantly enhance muscle mass in older adults. Both supplements also proved effective in reducing inflammatory markers and elevating testosterone levels. HT-PS23, administered as a heat-treated probiotic, provided more pronounced benefits to the elderly compared with its probiotic counterpart, L-PS23.
随着个体年龄的增长，肌肉质量和力量会逐渐丧失，这不仅会损害身体功能，还会增加老年人跌倒的风险并降低其独立性。由于益生菌通过肠 - 肌肉轴对增强肌肉健康具有潜在作用，因此已成为近期研究的重点。本研究评估了活的和热处理的PS23（PS23）补充剂对老年人肌肉力量和质量的影响。本研究招募了119名年龄在65 - 85岁之间的参与者，并将他们随机分配接受安慰剂（0×10CFU/天）、L - PS23（活的PS23，2×10CFU/天）或HT - PS23（热处理的PS23，2×10个细胞/天），为期12周。在基线、6周和12周时进行血压、身体成分、肌肉力量、功能性体能和生化参数的评估。在完成试验的100名受试者中，与安慰剂相比，补充L - PS23和HT - PS23均显著增强了下肢肌肉力量和耐力（<0.05），尽管各组之间在肌肉质量或上肢肌肉力量方面未观察到显著差异。此外，虽然大多数与肌肉合成代谢相关的标志物没有显著变化，但两种补充剂均有效降低了与衰老相关的炎症标志物——C反应蛋白（CRP：L - PS23， = 0.016；HT - PS23， = 0.013）和白细胞介素 - 6（IL - 6：L - PS23， = 0.003；HT - PS23，<0.001），并提高了白细胞介素 - 10水平（L - PS23， = 0.014；HT - PS23， = 0.005）。值得注意的是，只有HT - PS23组的睾酮水平有显著升高（ = 0.029）。补充L - PS23和HT - PS23 12周可改善老年人的下肢肌肉力量和耐力，但并未显著增加肌肉质量。两种补充剂在降低炎症标志物和提高睾酮水平方面也都被证明是有效的。作为热处理益生菌施用的HT - PS23与益生菌对应物L - PS23相比，为老年人提供了更显著的益处。
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