Tateishi Yuki, Nagasawa Shota, Iwabuchi Yoshiharu
Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aoba, Aramaki, Aoba-ku, Sendai 980-8578, Japan.
Org Lett. 2025 Feb 28;27(8):1984-1988. doi: 10.1021/acs.orglett.5c00287. Epub 2025 Feb 14.
Herein, we report a novel photocatalytic tandem Ueno-Stork cyclization/intermolecular Giese addition sequence for the stereoselective difunctionalization of allylic alcohols. This reaction avoids the use of toxic reagents and complicated protocols typically required under classical Ueno-Stork conditions. Furthermore, the reaction system demonstrated good stereoselectivity with both cyclic and linear allylic alcohols.
在此，我们报道了一种新型的光催化串联上野-斯托克环化/分子间吉泽加成序列，用于烯丙醇的立体选择性双官能团化。该反应避免了使用传统上野-斯托克条件下通常需要的有毒试剂和复杂方案。此外，该反应体系对环状和线性烯丙醇均表现出良好的立体选择性。
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