阿扎尔队列人群中肝酶、糖尿病前期和糖尿病之间的关系。
The relationship between hepatic enzymes, prediabetes, and diabetes in the Azar cohort population.
作者信息
Faramarzi Elnaz, Mehrtabar Saba, Molani-Gol Roghayeh, Dastgiri Saeed
机构信息
Liver and Gastrointestinal Diseases Research Center Tabriz, Tabriz University of Medical Sciences, Tabriz, Iran.
Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
出版信息
BMC Endocr Disord. 2025 Feb 14;25(1):41. doi: 10.1186/s12902-025-01871-x.
BACKGROUND
Early prediabetes screening holds immense significance in decreasing the incidence of diabetes. Therefore, we aimed to evaluate the association of hepatic enzymes with prediabetes and diabetes in the Azar cohort population in Iran.
METHODS
This cross-sectional study utilized data from the Azar cohort study, initiated in 2014, with 14,865 participants aged 35-70 years. This study defines prediabetes, according to the American Diabetes Association (ADA), as fasting blood sugar (FBS) of 100-125 mg/dl. An FBS ≥ 126 mg/dL or a history of diabetes indicates diabetes. Serum liver enzymes including alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl transferase (GGT), and alkaline phosphatase (ALP) were measured, and associations with prediabetes and diabetes were analyzed using binary logistic regression.
RESULTS
In a study of 14,865 participants, 16% had prediabetes and 14.1% had diabetes. The serum levels of ALT, AST, GGT, and ALP were significantly higher (P < 0.05) in the prediabetic and diabetic patients. The adjusted logistic regression model showed a dose-response increase for all hepatic enzymes, with the highest ORs in the fourth quartile for both prediabetes and diabetes. The highest OR for prediabetes and diabetes was in the fourth GGT quartile.
CONCLUSION
Our findings suggest that serum ALT, GGT, and ALP levels are strongly associated with prediabetes and diabetes. These hepatic enzymes may be considered easy and valuable early indicators of diabetes risk, prompting timely interventions to slow disease progression.
背景
早期糖尿病前期筛查对于降低糖尿病发病率具有重要意义。因此，我们旨在评估伊朗阿扎尔队列人群中肝酶与糖尿病前期及糖尿病之间的关联。
方法
这项横断面研究利用了阿扎尔队列研究的数据，该研究始于2014年，有14865名年龄在35 - 70岁的参与者。根据美国糖尿病协会（ADA）的标准，本研究将糖尿病前期定义为空腹血糖（FBS）为100 - 125mg/dl。空腹血糖≥126mg/dL或有糖尿病病史则表明患有糖尿病。检测了血清肝酶，包括丙氨酸氨基转移酶（ALT）、天冬氨酸氨基转移酶（AST）、γ-谷氨酰转移酶（GGT）和碱性磷酸酶（ALP），并使用二元逻辑回归分析其与糖尿病前期及糖尿病的关联。
结果
在对14865名参与者的研究中，16%患有糖尿病前期，14.1%患有糖尿病。糖尿病前期和糖尿病患者的ALT、AST、GGT和ALP血清水平显著更高（P < 0.05）。调整后的逻辑回归模型显示，所有肝酶均呈剂量反应性增加，糖尿病前期和糖尿病在第四四分位数时的比值比最高。糖尿病前期和糖尿病的最高比值比出现在GGT的第四四分位数。
结论
我们的研究结果表明，血清ALT、GGT和ALP水平与糖尿病前期及糖尿病密切相关。这些肝酶可能被视为简单且有价值的糖尿病风险早期指标，促使及时进行干预以减缓疾病进展。
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