Zhang Jiling, Wang Baodong, Du Peng, Song He, Yang Lihui, Zhou Yu
Department of Clinical Laboratory, Beijing Shunyi District Hospital, Beijing, China.
Department of Orthopedics, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
Medicine (Baltimore). 2025 Feb 14;104(7):e41536. doi: 10.1097/MD.0000000000041536.
The gut-disc axis, which refers to the interaction between gut microbiota and bone health, has recently garnered widespread attention in the scientific community. However, it remains to be determined whether gut microbiota directly induces cervical spondylosis (CS). This study employed a bidirectional 2-sample Mendelian randomization (MR) analysis to explore the potential causal link between gut microbiota and CS. We initially used the inverse variance weighted method for preliminary estimation and supplemented it with other MR methods, including MR-Egger, weighted median, weighted mode, and simple mode. Furthermore, we utilized the Cochrane Q test, MR-PRESSO global test, and MR-Egger intercept test to assess possible pleiotropy and heterogeneity. Ultimately, we conducted a bidirectional MR study to investigate potential reverse associations between gut microbiota and CS. The preliminary MR analysis identified 27 gut microbiota significantly associated with CS, of which 12 may be contributing factors, while 15 may have protective effects. The reverse MR analysis further revealed a potential causal relationship between CS and 24 gut microbiota. In this study, no significant heterogeneity or pleiotropy was detected. Through MR analysis, we uncovered a significant causal relationship between gut microbiota and CS, providing new perspectives for the prevention and treatment of CS, especially in the modulation of the microbiota.
肠-椎间盘轴是指肠道微生物群与骨骼健康之间的相互作用，最近在科学界引起了广泛关注。然而，肠道微生物群是否直接诱发颈椎病（CS）仍有待确定。本研究采用双向两样本孟德尔随机化（MR）分析来探讨肠道微生物群与CS之间的潜在因果关系。我们最初使用逆方差加权法进行初步估计，并辅以其他MR方法，包括MR-Egger法、加权中位数法、加权众数法和简单众数法。此外，我们利用Cochrane Q检验、MR-PRESSO全局检验和MR-Egger截距检验来评估可能的多效性和异质性。最终，我们进行了双向MR研究，以调查肠道微生物群与CS之间潜在的反向关联。初步的MR分析确定了27种与CS显著相关的肠道微生物群，其中12种可能是促成因素，而15种可能具有保护作用。反向MR分析进一步揭示了CS与24种肠道微生物群之间的潜在因果关系。在本研究中，未检测到显著的异质性或多效性。通过MR分析，我们发现了肠道微生物群与CS之间的显著因果关系，为CS的预防和治疗提供了新的视角，特别是在微生物群的调节方面。
