Jiao Haishan, Huang Shuyi, Cheng Wei, Feng Jianfeng, Yu Jintai
Department of Neurology and Institute of Neurology, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College, Fudan University, Shanghai 200040, China.
Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai 200433, China.
Chin Med J (Engl). 2025 Apr 5;138(7):819-828. doi: 10.1097/CM9.0000000000003399. Epub 2025 Feb 19.
Physical activity, sedentary behavior (SB), and sleep duration are associated with brain health. Effects of those on developing Parkinson's disease (PD) are poorly investigated. This study aimed to examine the independent and joint associations of physical activity, SB, sleep with PD risk.
We analyzed data on 401,697 participants from the UK Biobank cohort, which was enrolled in 2006-2010. Physical activities were measured based on a questionnaire. Sleep and SB time were defined through self-reported total number of hours. Models fitted with restricted cubic spline were conducted to test for linear and non-linear shapes of each association. Cox proportional hazards regression models were used to estimate the association of three modifiable behaviors.
Our analytic sample included 401,697 participants with 3030 identified cases of PD (mean age, 63 years; 62.9% male). PD risk was 18% lower in the high total physical activity group (95% CI, 0.75-0.90), 22% lower in the high leisure-time physical activity (LTPA) group (95% CI, 0.71-0.86) compared with the low level and 14% higher in the high sleep duration group (95% CI, 1.05-1.24) compared to moderate group. Total SB time was irrelevant with PD risk, while high TV viewing showed a 12% increase of PD risk compared to the low group (95% CI, 1.02-1.22). Low computer use (0 h/day) was associated with a 14% higher risk compared to 1 h/day use (95% CI, 1.04-1.26). Those associations were independent. A combination of 7 h/day sleep, moderate-to-high computer use, and moderate-to-vigorous intensity of LTPA showed lowest PD risk (HR, 0.70; 95% CI, 0.57-0.85).
Physical activity, SB, and sleep were associated with PD risks separately. Our findings emphasize the possibility for changing these three daily activities concurrently to lower the risk of PD. These findings may promote an active lifestyle for PD prevention.
身体活动、久坐行为（SB）和睡眠时间与大脑健康相关。它们对帕金森病（PD）发病的影响研究较少。本研究旨在探讨身体活动、SB和睡眠与PD风险的独立及联合关联。
我们分析了英国生物银行队列中401,697名参与者的数据，该队列于2006 - 2010年招募。基于问卷测量身体活动。睡眠和SB时间通过自我报告的小时总数来定义。采用限制立方样条拟合模型来检验各关联的线性和非线性形态。使用Cox比例风险回归模型来估计三种可改变行为的关联。
我们的分析样本包括401,697名参与者，其中确诊PD患者3030例（平均年龄63岁；男性占62.9%）。与低水平组相比，高总体身体活动组的PD风险降低18%（95%CI，0.75 - 0.90），高休闲时间身体活动（LTPA）组降低22%（95%CI，0.71 - 0.86）；与中等睡眠时间组相比，高睡眠时间组的PD风险升高14%（95%CI，1.05 - 1.24）。总SB时间与PD风险无关，而与低观看电视组相比，高观看电视组的PD风险升高12%（95%CI，1.02 - 1.22）。低电脑使用时间（0小时/天）与1小时/天使用相比，风险升高14%（95%CI，1.04 - 1.26）。这些关联是独立的。每天睡眠7小时、中等至高电脑使用时间以及中等至剧烈强度的LTPA相结合，显示出最低的PD风险（HR，0.70；95%CI，0.57 - 0.85）。
身体活动、SB和睡眠分别与PD风险相关。我们的研究结果强调了同时改变这三种日常活动以降低PD风险的可能性。这些发现可能会促进一种积极的生活方式来预防PD。
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