Berkowitz Seth A, Ochoa Aileen, LaPoint Myklynn, Kuhn Marlena L, Dankovchik Jenine, Donovan Jenna M, Gao Mufeng, Basu Sanjay, Hudgens Michael G, Gold Rachel
University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.
University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
J Prim Care Community Health. 2025 Jan-Dec;16:21501319251320709. doi: 10.1177/21501319251320709.
To estimate associations between transportation barriers and diabetes outcomes.
Longitudinal cohort study; 86 977 adults with type 2 diabetes mellitus in community-based health centers were assessed for transportation barriers, with up to 36 months of follow-up after initial assessment. We compared scenarios in which individuals did not experience transportation barriers to scenarios in which they did, to estimate differences in mean hemoglobin a1c (HbA1c), systolic and diastolic blood pressure (SBP and DBP), and LDL cholesterol. For analysis, we used targeted minimum loss estimation at the following timepoints after initial transportation barrier assessment: 12 (primary), 6, 18, 24, 30, and 36 months. The study period was June 24, 2016 to April 30, 2023.
We estimated that if participants did not experience transportation barriers, mean HbA1c would have been 0.09% lower (95% CI = -0.14% to -0.04%, = .0002) at 12 months, compared to a scenario in which they did experience transportation barriers. These results were similar at other time points. We also estimated that absence of transportation barriers was associated with, at 12 months, lower SBP (-0.6mm Hg, 95% CI = -1.0mm Hg to -0.2mm Hg, = .004) and DBP (-0.3mm Hg, 95% CI = -0.5mm Hg to -0.1mm Hg, = .02), but not LDL (-1.1mg/dL, 95% CI = -2.6 mg/dL to 0.5 mg/dL, = .19). Results at other time points for SBP, DBP, and LDL outcomes were similar.
Absence of transportation barriers was associated with slightly lower hemoglobin A1c and blood pressure, but the small magnitude of the differences suggests that also addressing other factors may be needed to improve diabetes outcomes more meaningfully.
评估交通障碍与糖尿病结局之间的关联。
纵向队列研究;对社区卫生中心的86977名2型糖尿病成年人进行交通障碍评估,初次评估后随访长达36个月。我们将个体未经历交通障碍的情况与经历交通障碍的情况进行比较,以估计平均糖化血红蛋白(HbA1c)、收缩压和舒张压(SBP和DBP)以及低密度脂蛋白胆固醇的差异。为进行分析,我们在初次交通障碍评估后的以下时间点使用目标最小损失估计:12个月(主要时间点)、6个月、18个月、24个月、30个月和36个月。研究期间为2016年6月24日至2023年4月30日。
我们估计,如果参与者未经历交通障碍,与经历交通障碍的情况相比,12个月时平均HbA1c会低0.09%(95%CI = -0.14%至-0.04%,P = 0.0002)。在其他时间点结果相似。我们还估计,在12个月时,没有交通障碍与较低的收缩压(-0.6mmHg,95%CI = -1.0mmHg至-0.2mmHg,P = 0.004)和舒张压(-0.3mmHg,95%CI = -0.5mmHg至-0.1mmHg,P = 0.02)相关,但与低密度脂蛋白无关(-1.1mg/dL,95%CI = -2.6mg/dL至0.5mg/dL,P = 0.19)。收缩压、舒张压和低密度脂蛋白结局在其他时间点的结果相似。
没有交通障碍与糖化血红蛋白和血压略低相关,但差异幅度较小,这表明可能还需要解决其他因素,才能更有意义地改善糖尿病结局。