Synergistic polyphenol-amino acid nanoparticles: a new strategy for reactive oxygen species management.

Polyphenols exhibit strong antioxidant, and anti-inflammatory but are limited by chemical instability and low bioavailability. To address these challenges, we developed polyphenol-amino acid conjugates that self-assemble into stable nanospheres, enhancing their stability and bioavailability. These nanoparticles demonstrate significantly improved ROS scavenging efficiency and promote cell proliferation . The incorporation of amino acids enhances biocompatibility and facilitates effective ROS elimination. The polyphenol-amino acid nanoparticles offer a multifaceted therapeutic strategy to mitigate oxidative stress, overcoming traditional antioxidant limitations through advanced nanotechnology. This approach contributes to the development of next-generation wound care solutions with enhanced efficacy and safety profiles.