Beiser Moshe, Sabari Joshua K
Langone Department of Internal Medicine, New York University, New York, NY, USA.
Perlmutter Cancer Center, New York University Langone Health, New York, NY, USA.
Case Rep Oncol. 2025 Jan 14;18(1):107-112. doi: 10.1159/000542928. eCollection 2025 Jan-Dec.
Good syndrome is defined as the co-occurrence of a thymoma and hypogammaglobulinemia.
In this case report, we present a patient who was diagnosed with Good syndrome following recurrent infections with SARS-CoV-2. Of particular note was the patient's repeated presentation despite receiving outpatient treatment with nirmatrelvir-ritonavir. We describe the patient's presentation, diagnosis, and treatment - including robotic thymectomy and passive immunization with IVIG - and report the benefit to quality of life that the patient experienced.
This case highlights the importance of quantitative testing of immunoglobulins in patients with known thymomas who present with recurrent infections of SARS-CoV-2.
古德综合征的定义为胸腺瘤与低丙种球蛋白血症同时出现。
在本病例报告中，我们介绍了一名患者，该患者在感染严重急性呼吸综合征冠状病毒2（SARS-CoV-2）后反复感染，被诊断为古德综合征。特别值得注意的是，尽管该患者接受了奈玛特韦-利托那韦的门诊治疗，但仍反复出现症状。我们描述了该患者的症状、诊断和治疗情况，包括机器人辅助胸腺切除术和静脉注射免疫球蛋白（IVIG）被动免疫，并报告了患者生活质量得到改善的情况。
本病例强调了对已知患有胸腺瘤且出现SARS-CoV-2反复感染的患者进行免疫球蛋白定量检测的重要性。
