Hránková Viktória, Balner Tomáš, Kondé Adéla, Gubová Patrícia, Zeleník Karol, Komínek Pavel, Staníková Lucia
Department of Otorhinolaryngology and Head and Neck Surgery, University Hospital of Ostrava, Ostrava, Czech Republic.
Department of Craniofacial Surgery, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic.
Eur Arch Otorhinolaryngol. 2025 Apr;282(4):2009-2013. doi: 10.1007/s00405-025-09258-3. Epub 2025 Feb 24.
To evaluate the role of an anti-reflux diet in the treatment of patients with chronic cough caused by laryngopharyngeal reflux (LPR).
This prospective observational study included patients with chronic cough (lasting over 3 months) and laryngopharyngeal reflux (LPR) confirmed by hypopharyngeal-esophageal 24-h multichannel intraluminal impedance-pH monitoring (HEMII-pH), according to Dubai criteria. Participants were categorized based on cough severity using a visual analog scale (VAS) from 1 to 10. A VAS < 5 was considered to indicate mild cough, whereas a VAS ≥ 5 were considered to indicate severe cough. Patients with mild cough were treated by anti-reflux diet only, while those with severe cough received additional treatment with proton pump inhibitors (PPIs) and alginates. After 3 months, treatment effectiveness was evaluated by assessing the reduction in cough severity.
In patients with mild cough, anti-reflux diet alone proved to be effective, yielding improvement in 83.3% of cases. Among patients with severe cough, a combination of anti-reflux diet, proton pump inhibitors (PPIs), and alginates proved was effective in 81.8% of cases.
Diet alone is an effective and sufficient treatment for mild chronic cough in patients with LPR. For patients with severe chronic cough with LPT, combined anti-reflux measures are effective.
评估抗反流饮食在治疗喉咽反流(LPR)所致慢性咳嗽患者中的作用。
这项前瞻性观察性研究纳入了根据迪拜标准经下咽-食管24小时多通道腔内阻抗-pH监测(HEMII-pH)确诊为慢性咳嗽(持续超过3个月)和喉咽反流(LPR)的患者。使用1至10的视觉模拟量表(VAS)根据咳嗽严重程度对参与者进行分类。VAS<5被认为表示轻度咳嗽,而VAS≥5被认为表示重度咳嗽。轻度咳嗽患者仅采用抗反流饮食治疗,而重度咳嗽患者则额外接受质子泵抑制剂(PPI)和藻酸盐治疗。3个月后,通过评估咳嗽严重程度的降低来评估治疗效果。
在轻度咳嗽患者中,单独使用抗反流饮食被证明是有效的,83.3%的病例有改善。在重度咳嗽患者中,抗反流饮食、质子泵抑制剂(PPI)和藻酸盐联合使用在81.8%的病例中被证明是有效的。
对于LPR患者的轻度慢性咳嗽,仅饮食治疗是一种有效且充分的治疗方法。对于LPT重度慢性咳嗽患者,联合抗反流措施是有效的。