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阿托品给药后出现严重高血压:一例报告

Severe hypertension after atropine administration a case report.

作者信息

Timerga Sara, Befkadu Aynalem

机构信息

Department of Anesthesia, College of Medicine and Health Sciences, Wollo University, Dessie, Ethiopia.

出版信息

Int J Emerg Med. 2025 Feb 24;18(1):32. doi: 10.1186/s12245-025-00832-4.

Abstract

Atropine, a cholinergic receptor antagonist, counteracts the parasympathetic nervous system's inhibitory effects on the sinus node, thereby increasing heart rate. It is frequently used to manage atrioventricular block, organophosphate and beta-blocker poisoning, and sinus bradycardia. This case report highlights a rare instance of hypertensive urgency induced by atropine administration, emphasizing the clinical significance of this adverse effect. We present a case report involving a 48-year-old male patient scheduled for right inguinal hernia surgery. The patient was administered atropine prior to the procedure and subsequently experienced severe hypertension and a headache, which were treated with labetalol. After 24 h of monitoring, the patient was discharged without further complications. Documenting such cases is crucial for enhancing our understanding of atropine's safety profile and refining management strategies to mitigate associated risks. CLINICAL TRIAL NUMBER: Not applicable.

摘要

阿托品是一种胆碱能受体拮抗剂,可抵消副交感神经系统对窦房结的抑制作用,从而提高心率。它常用于治疗房室传导阻滞、有机磷和β受体阻滞剂中毒以及窦性心动过缓。本病例报告突出了因使用阿托品导致高血压急症这一罕见情况,强调了这种不良反应的临床意义。我们报告一例48岁男性患者,计划行右腹股沟疝修补术。患者在手术前使用了阿托品,随后出现严重高血压和头痛,使用拉贝洛尔进行了治疗。经过24小时监测,患者出院,无进一步并发症。记录此类病例对于增进我们对阿托品安全性的了解以及完善管理策略以降低相关风险至关重要。临床试验编号:不适用。

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本文引用的文献

1
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Hypertension. 2024 Aug;81(8):e94-e106. doi: 10.1161/HYP.0000000000000238. Epub 2024 May 28.
2
Hypertensive emergency secondary to atropine.
Hipertens Riesgo Vasc. 2024 Jan-Mar;41(1):58-61. doi: 10.1016/j.hipert.2023.08.003. Epub 2024 Feb 24.
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Atropine augments cardiac contractility by inhibiting cAMP-specific phosphodiesterase type 4.
Sci Rep. 2017 Nov 9;7(1):15222. doi: 10.1038/s41598-017-15632-x.
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Atropine and a hypertensive crisis.
Ann Intern Med. 1984 Nov;101(5):720. doi: 10.7326/0003-4819-101-5-720_1.

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