灼口综合征患者疼痛预后、药物疗效、治疗意愿及影响因素分析：一项横断面调查

Analysis of pain prognosis, medication efficacy, treatment willingness and influencing factors in patients with burning mouth syndrome: a cross-sectional survey.

作者信息

Zhang Qi, Tan Zhongke, Ma Qianqian, Guo Jiaao, Yang Yanjie

机构信息

Department of Stomatology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

National Engineering Laboratory for Internet Medical Systems and Applications, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

出版信息

BMC Oral Health. 2025 Feb 24;25(1):300. doi: 10.1186/s12903-025-05674-3.

DOI:10.1186/s12903-025-05674-3

PMID:39994648

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11853313/

Abstract

OBJECTIVE

To explore the pain prognosis, medication efficacy and treatment willingness of patients with burning mouth syndrome (BMS) and to identify the factors influencing the pain prognosis, medication efficacy and treatment willingness of patients with BMS.

METHODS

Medical records of patients who were clinically diagnosed with BMS and who complained of oral mucosal pain at the Department of Stomatology, The First Affiliated Hospital of Zhengzhou University, were retrospectively collected from January 2019 to April 2022. Telephone follow-ups were conducted in August 2024 to investigate the patients' pain prognosis, medication efficacy, willingness for treatment and related treatment information.

RESULTS

Among the 192 patients, only 31.77% (61/192) reported complete elimination of pain; 37.50% (72/192) reported that the pain still existed but had improved, and 30.73% (59/192) reported no improvement at all. A total of 31.25% (60/192), 34.90% (67/192), and 32.81% (63/192) of the BMS patients evaluated medication efficacy as significantly effective, effective, or ineffective, respectively. Among the 131 patients who still had pain symptoms, 38.17% (50/131) intended to continue treatment. Logistic regression revealed that patients who were older (P = 0.023), who had visited multiple hospitals for treatment (P = 0.001), who were afraid of cancer (P = 0.011) and who were prone to anxiety or depression (P < 0.001) had poorer pain improvement. Patients who had visited multiple hospitals (P < 0.001) and those who were prone to anxiety or depression (P < 0.001) had significantly lower evaluations of medication efficacy. Males (P = 0.041) and those who had visited multiple hospitals (P < 0.001) were more willing to continue treatment.

CONCLUSION

The prognosis for most BMS patients tends to be relatively poor. Age, anxiety or depression, and fear of cancer may affect the pain prognosis of patients with BMS, whereas psychological factors may also impact the efficacy of medication.

摘要

目的

探讨灼口综合征（BMS）患者的疼痛预后、药物疗效及治疗意愿，并确定影响BMS患者疼痛预后、药物疗效及治疗意愿的因素。

方法

回顾性收集2019年1月至2022年4月在郑州大学第一附属医院口腔科临床诊断为BMS且主诉口腔黏膜疼痛患者的病历资料。2024年8月进行电话随访，调查患者的疼痛预后、药物疗效、治疗意愿及相关治疗信息。

结果

192例患者中，仅31.77%（61/192）报告疼痛完全消除；37.50%（72/192）报告疼痛仍存在但有所改善，30.73%（59/192）报告完全无改善。分别有31.25%（60/192）、34.90%（67/192）和32.81%（63/192）的BMS患者将药物疗效评估为显著有效、有效或无效。在仍有疼痛症状的131例患者中，38.17%（50/131）打算继续治疗。逻辑回归显示，年龄较大（P = 0.023）、曾到多家医院就诊（P = 0.001）、害怕患癌（P = 0.011）以及易焦虑或抑郁（P < 0.001）的患者疼痛改善较差。曾到多家医院就诊（P < 0.001）以及易焦虑或抑郁（P < 0.001）的患者对药物疗效的评估显著较低。男性（P = 0.041）和曾到多家医院就诊的患者（P < 0.001）更愿意继续治疗。