Biener Leonie, Budimovska Andrea, Skowasch Dirk, Pizarro Carmen, Frisch Ben Christoph, Nickenig Georg, Stumpf Max Jonathan, Schaefer Christian A, Schahab Nadjib
Department of Internal Medicine II - Cardiology, Pneumology and Angiology, University of Bonn, Bonn, Germany.
J Asthma Allergy. 2025 Feb 20;18:245-255. doi: 10.2147/JAA.S483504. eCollection 2025.
Asthma is associated with atherosclerosis and abdominal aortic aneurysm (AAA). However, the underlying pathomechanisms remain elusive. Blood eosinophil count (BEC) is implicated in both eosinophilic asthma and arterial wall inflammation.
To explore the possible association of BEC in asthma and abdominal aortic artery changes.
112 outpatients were prospectively enrolled in this exploratory study. Abdominal aortic diameter was measured using ultrasonography imaging, while vascular speckle tracking was utilized to evaluate vascular strains. Patients were stratified into two groups, with n=66 patients with a BEC of ≥300 n/µL and n=46 patients with <300 n/µL. Both groups exhibited no significant disparities in cardiovascular risk factors; however, the high BEC group was more frequently male.
The aortic diameter was wider in patients with a BEC ≥300 n/µL (1.46 ± 0.25 cm vs 1.67 ± 0.63 cm, p=0.018). Three patients were diagnosed with an AAA, all had a BEC ≥300 n/µL. Patients with a BEC ≥300 n/µL exhibited lower strain values, indicative of higher vascular stiffness, including radial strain (2.65 ± 1.38% vs 4.46 ± 2.59%; p<0.001). BEC exhibited a positive correlation with abdominal aortic diameter (R²=0.131, b=0.000, p<0.001), and a negative correlation with radial strain values (R²=0.131, b=-0.002, p=0.001) in sex-adjusted linear regression.
In patients with asthma, blood eosinophil count (BEC) is correlated with a wider aortic diameter and heightened vascular stiffness in the abdominal aorta. Hence, they may be at an elevated risk of developing an AAA.
哮喘与动脉粥样硬化和腹主动脉瘤（AAA）有关。然而，潜在的病理机制仍不清楚。血液嗜酸性粒细胞计数（BEC）与嗜酸性粒细胞性哮喘和动脉壁炎症均有关。
探讨哮喘患者的BEC与腹主动脉变化之间的可能关联。
112名门诊患者被前瞻性纳入这项探索性研究。使用超声成像测量腹主动脉直径，同时利用血管散斑追踪评估血管应变。患者被分为两组，66名患者的BEC≥300 n/µL，46名患者的BEC<300 n/µL。两组在心血管危险因素方面无显著差异；然而，高BEC组男性更为常见。
BEC≥300 n/µL的患者主动脉直径更宽（1.46±0.25 cm对1.67±0.63 cm，p=0.018）。3名患者被诊断为AAA，均有BEC≥300 n/µL。BEC≥300 n/µL的患者表现出较低的应变值，表明血管僵硬度较高，包括径向应变（2.65±1.38%对4.46±2.59%；p<0.001）。在性别调整的线性回归中，BEC与腹主动脉直径呈正相关（R²=0.131，b=0.000，p<0.001），与径向应变值呈负相关（R²=0.131，b=-0.002，p=0.001）。
在哮喘患者中，血液嗜酸性粒细胞计数（BEC）与更宽的主动脉直径和更高的腹主动脉血管僵硬度相关。因此，他们可能有更高的AAA发生风险。
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