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抗氧化化合物的多靶点分析,包括重新利用和联合策略。

Multi-Target Profiling of Antioxidant Compounds, Including Repurposing and Combination Strategies.

作者信息

Rocca Roberta

机构信息

Department of Health Sciences, University Magna Græcia, 88100 Catanzaro, Italy.

出版信息

Antioxidants (Basel). 2025 Feb 15;14(2):220. doi: 10.3390/antiox14020220.

Abstract

Multifactorial diseases, such as cancer, neurodegenerative disorders, and stroke, present significant challenges in modern medicine due to their complex origins and the absence of definitive treatments [...].

摘要

诸如癌症、神经退行性疾病和中风等多因素疾病,因其起源复杂且缺乏确切的治疗方法,给现代医学带来了重大挑战[……]。

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本文引用的文献

1
Reactive oxygen species, toxicity, oxidative stress, and antioxidants: chronic diseases and aging.
Arch Toxicol. 2023 Oct;97(10):2499-2574. doi: 10.1007/s00204-023-03562-9. Epub 2023 Aug 19.
2
Polypharmacology: promises and new drugs in 2022.
Pharmacol Rep. 2023 Aug;75(4):755-770. doi: 10.1007/s43440-023-00501-4. Epub 2023 Jun 6.
3
What are the challenges with multi-targeted drug design for complex diseases?
Expert Opin Drug Discov. 2022 Jul;17(7):673-683. doi: 10.1080/17460441.2022.2072827. Epub 2022 May 12.
5
A perspective on multi-target drug discovery and design for complex diseases.
Clin Transl Med. 2018 Jan 17;7(1):3. doi: 10.1186/s40169-017-0181-2.
6
Computer Aided Drug Design for Multi-Target Drug Design: SAR /QSAR, Molecular Docking and Pharmacophore Methods.
Curr Drug Targets. 2017;18(5):556-575. doi: 10.2174/1389450117666160101120822.

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