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胚胎选择、基因编辑与人的影响原则。

Embryo selection, gene editing, and the person-affecting principle.

作者信息

Wang Xueshi

机构信息

School of Humanities and Social Science, The Chinese University of Hong Kong, Shenzhen, China.

出版信息

Bioethics. 2025 Jul;39(6):594-601. doi: 10.1111/bioe.13407. Epub 2025 Feb 26.

Abstract

This article examines the ethical implications of embryo selection (ES) and gene editing (GE) in reproductive medicine through the lens of Pummer's Person-Affecting View (PAV). I argue that even if the edited embryo is not numerically identical to the unedited one, GE may still be ethically preferable to ES in certain scenarios. PAV assesses the moral permissibility of an action based on the balance of requiring reasons against and permitting reasons for it, from the perspective of particular individuals. I apply PAV to ES/GE decisions, considering the expected happiness and suffering of potential future children. The permissibility of ES or GE depends on the nature of the genetic disorder and the balance of expected happiness and suffering in each case.

摘要

本文通过普默的“影响人观点”(PAV)审视生殖医学中胚胎选择(ES)和基因编辑(GE)的伦理影响。我认为,即使经过编辑的胚胎与未编辑的胚胎在数量上并非同一,在某些情况下,基因编辑在伦理上仍可能优于胚胎选择。“影响人观点”从特定个体的角度,根据反对的要求性理由与支持的允许性理由之间的平衡来评估一个行为的道德可允许性。我将“影响人观点”应用于胚胎选择/基因编辑决策,考虑潜在未来儿童的预期幸福和痛苦。胚胎选择或基因编辑的可允许性取决于遗传疾病的性质以及每种情况下预期幸福与痛苦的平衡。

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