Solomon Regina N, Pittner Nicholas A, McCoy Jaclyn R, Warwick Paityn A, McBride Jere W
Department of Pathology, University of Texas Medical Branch, Galveston, TX, United States.
Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, United States.
Front Cell Infect Microbiol. 2025 Feb 14;15:1539847. doi: 10.3389/fcimb.2025.1539847. eCollection 2025.
() has recently emerged as an intracellular bacterial pathogen with sophisticated survival mechanisms that include repurposing evolutionarily conserved eukaryotic cell signaling pathways for immune evasion. exploits four major developmental signaling pathways (Wnt, Notch, Hedgehog, and Hippo) using short linear motif (SLiM) ligand mimicry to initiate signaling cascades. Dysregulation of these major signaling pathways leading to unchecked cell survival is implicated in various diseases, most notably cancer. exploits Wnt, Notch, Hedgehog and Hippo signaling pathways to inhibit apoptosis and co-opt other cellular functions to promote infection. This review will explore the signaling pathways exploited during infection and the new discoveries that have illuminated this interesting example of the cell signaling convergence in cellular infection and cancer biology.
（）最近已成为一种细胞内细菌病原体，具有复杂的生存机制，包括重新利用进化上保守的真核细胞信号通路进行免疫逃避。利用短线性基序（SLiM）配体模拟来利用四种主要的发育信号通路（Wnt、Notch、Hedgehog和Hippo）启动信号级联反应。这些主要信号通路的失调导致不受控制的细胞存活，与各种疾病有关，最显著的是癌症。利用Wnt、Notch、Hedgehog和Hippo信号通路来抑制细胞凋亡并选择其他细胞功能以促进感染。本综述将探讨在感染过程中利用的信号通路以及揭示细胞感染和癌症生物学中细胞信号汇聚这一有趣例子的新发现。
