[Acute promyelocytic leukemia with disseminated intravascular coagulation: a case report and literature review].
作者信息
Gu W J, Fu R F, Zhang L, Yang R C, Liu X F
机构信息
State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China Tianjin Institutes of Health Science, Tianjin 301600, China.
State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China Tianjin Institutes of Health Science, Tianjin 301600, China School of Population Medicine and Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
出版信息
Zhonghua Xue Ye Xue Za Zhi. 2024 Dec 30;45(S1):85-88. doi: 10.3760/cma.j.cn121090-20241130-00502.
Acute promyelocytic leukemia (APL) is characterized by an aggressive onset and rapid progression. During induction chemotherapy, it is prone to being complicated by disseminated intravascular coagulation (DIC), which is a leading cause of early death in patients. This study reports a case of APL complicated by DIC during induction therapy with all-trans retinoic acid (ATRA) combined with arsenic trioxide (ATO). The patient's coagulopathy was corrected through active transfusion of blood products and replacement therapy with coagulation factors. Subsequently, complete remission was achieved after multiple courses of chemotherapy. This article provides a detailed description of the patient's disease onset and treatment process, exploring the differences in pathogenesis, clinical presentation, and treatment strategies between APL-associated DIC and DIC caused by other diseases, alongside a review of the relevant literature.
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