Role of Triple-Negative Breast Cancer-Derived Extracellular Vesicles in Metastasis: Implications for Therapeutics and Biomarker Development.

Triple-negative breast cancer (TNBC) is a highly aggressive form of breast cancer with a poor prognosis and high mortality. The chemotherapeutic regimen remains the predominant treatment modality for TNBC in current clinical practice. However, chemotherapy resistance significantly complicates the development of an effective treatment regimen. Furthermore, the immunosuppressive microenvironment of TNBC contributes to enhanced tumour aggressiveness. Consequently, understanding its mechanisms of progression and finding effective therapeutic interventions is crucial. Recent evidence has identified extracellular vesicles (EVs) as key mediators of cell-to-cell communication in TNBC progression and immune regulation. In view of the remarkable ability of EVs to transfer active molecules, such as proteins and nucleic acids, from parental to recipient cells, they are regarded as a promising biomarker and novel drug delivery system. In this review, we provide an overview of how EVs derived from TNBC cells and tumour microenvironment cells play a role in regulating tumour progression. We also discuss the potential of EVs for immune regulation and their application as novel therapeutic strategies and tumour markers in TNBC. The knowledge gained from studying EV-mediated communication in TNBC could lead to the development of targeted therapies and improve patient outcomes.