Chen Xiaoxiao, Yin Rulan, Lu Minxia, Mao Lifen, Lu Jing, Wang Meng, Shi Xiaoqing
Department of Nursing, The First Affiliated Hospital of Soochow University, Suzhou, China.
School of Nursing, Medical College of Soochow University, Suzhou, China.
Nurs Open. 2025 Mar;12(3):e70178. doi: 10.1002/nop2.70178.
The intersection of heart failure (HF) and serum chloride is of increasing interest; however, estimates of the global prevalence of hypochloremia in HF were inconsistent. This paper aimed to quantify the current prevalence of hypochloremia in patients with HF.
Systematic review and meta-analysis.
PubMed, Cochrane, Embase, Web of Science, and CINAHL databases were systematically searched from inception to May 24, 2022. Observational studies that clearly defined the cutoff for hypochloremia and provided the prevalence of hypochloremia in patients with HF were included. Stata 17.0 was used for data analysis. Heterogeneity was assessed according to Cochran's Q and I values, and results were pooled using a random-effects model. Sensitivity analysis, subgroup analysis, and meta-regression were used to explore the sources of heterogeneity.
Sixteen papers reporting 18 studies that involved 29,807 patients with HF were included in the meta-analysis. The pooled prevalence of hypochloremia in HF was 14.0% (95% CI: 11.9%-16.2%; I = 96.6%, I CI: 95.6%-97.4%, p < 0.001). Study country and study quality were identified in subgroup analysis and meta-regression as possible sources of heterogeneity. Funnel plot and egger's test revealed publication bias (p = 0.02).
No patient or public contribution.
心力衰竭（HF）与血清氯的关联日益受到关注；然而，关于HF中低氯血症全球患病率的估计并不一致。本文旨在量化目前HF患者中低氯血症的患病率。
系统评价和荟萃分析。
从数据库建立至2022年5月24日，对PubMed、Cochrane、Embase、Web of Science和CINAHL数据库进行系统检索。纳入明确界定低氯血症临界值并提供HF患者低氯血症患病率的观察性研究。使用Stata 17.0进行数据分析。根据Cochran's Q和I值评估异质性，并使用随机效应模型汇总结果。采用敏感性分析、亚组分析和Meta回归探索异质性来源。
荟萃分析纳入了16篇报告18项研究，涉及29807例HF患者。HF中低氯血症的合并患病率为14.0%（95%CI：11.9%-16.2%；I² = 96.6%，I²CI：95.6%-97.4%，p < 0.001）。亚组分析和Meta回归确定研究国家和研究质量可能是异质性来源。漏斗图和Egger检验显示存在发表偏倚（p = 0.02）。
无患者或公众参与。
