Suppr超能文献

生物医学应用中的磁性聚合物导管

Magnetic Polymeric Conduits in Biomedical Applications.

作者信息

Ganguly Sayan, Margel Shlomo

机构信息

Department of Chemistry, University of Waterloo, Waterloo, ON N2L 3G1, Canada.

Department of Chemistry, Bar-Ilan Institute for Nanotechnology and Advanced Materials (BINA), Bar-Ilan University, Ramat-Gan 5290002, Israel.

出版信息

Micromachines (Basel). 2025 Jan 31;16(2):174. doi: 10.3390/mi16020174.

Abstract

Magnetic polymeric conduits are developing as revolutionary materials in regenerative medicine, providing exceptional benefits in directing tissue healing, improving targeted medication administration, and facilitating remote control via external magnetic fields. The present article offers a thorough examination of current progress in the design, construction, and functionalization of these hybrid systems. The integration of magnetic nanoparticles into polymeric matrices confers distinctive features, including regulated alignment, improved cellular motility, and targeted medicinal delivery, while preserving structural integrity. Moreover, the incorporation of multifunctional attributes, such as electrical conductivity for cerebral stimulation and optical characteristics for real-time imaging, expands their range of applications. Essential studies indicate that the dimensions, morphology, surface chemistry, and composition of magnetic nanoparticles significantly affect their biocompatibility, degrading characteristics, and overall efficacy. Notwithstanding considerable advancements, issues concerning long-term biocompatibility, biodegradability, and scalability persist, in addition to the must for uniform regulatory frameworks to facilitate clinical translation. Progress in additive manufacturing and nanotechnology is overcoming these obstacles, facilitating the creation of dynamic and adaptive conduit structures designed for particular biomedical requirements. Magnetic polymeric conduits, by integrating usefulness and safety, are set to transform regenerative therapies, presenting a new avenue for customized medicine and advanced healthcare solutions.

摘要

磁性聚合物导管正在成为再生医学中的革命性材料,在引导组织愈合、改善靶向药物给药以及通过外部磁场实现远程控制方面具有显著优势。本文对这些混合系统在设计、构建和功能化方面的当前进展进行了全面审视。将磁性纳米颗粒整合到聚合物基质中赋予了独特的特性,包括可控排列、改善细胞运动性以及靶向药物递送,同时保持结构完整性。此外,加入多功能属性,如用于脑刺激的导电性和用于实时成像的光学特性,扩大了它们的应用范围。重要研究表明,磁性纳米颗粒的尺寸、形态、表面化学和组成显著影响其生物相容性、降解特性和整体功效。尽管取得了相当大的进展,但除了需要统一的监管框架以促进临床转化外,长期生物相容性、生物降解性和可扩展性问题仍然存在。增材制造和纳米技术的进展正在克服这些障碍,有助于创建针对特定生物医学需求设计的动态和适应性导管结构。通过整合实用性和安全性,磁性聚合物导管必将改变再生疗法,为定制医学和先进医疗解决方案开辟一条新途径。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f678/11857720/7cd31013021a/micromachines-16-00174-g001.jpg

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验