Tan Siqi, Chen Ziyan, Yunyao Liu, Hedan Yang, Lin Tong
Department of Laser Surgery, Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, China.
Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China.
Arch Dermatol Res. 2025 Mar 8;317(1):529. doi: 10.1007/s00403-025-04023-2.
The skin, as the largest organ in the human body, serves as the primary physical barrier and plays a crucial role in the immune defense process. Immune-related skin diseases encompass a spectrum of complex dermatological conditions characterized by aberrant immune responses, including the production of autoantibodies and dysregulation of inflammatory mediators. Growing evidence suggest a heightened prevalence of comorbid neuropsychiatric disorders among patients with immune-related skin diseases, indicative of potential shared pathogenesis. In recent years, the brain connectome, delineating the intricate network of neural connections, has gained prominence in elucidating various neurological and psychiatric conditions. Researchers have begun to investigate whether alterations in brain connectivity occur in patients with immune-related skin diseases, thereby exploring the connectome perspective in understanding the pathogenesis of these diseases. This review aims to synthesize and analyze recent neuroimaging studies about immune-related skin diseases, including systemic lupus erythematosus, psoriasis, chronic spontaneous urticaria, and atopic dermatitis. We mainly discussed the connectome studies related to these diseases and summarized the underlying mechanisms associated with their clinical manifestations, progression, and treatment. Then from our perspectives, we believe that interdisciplinary collaborations encompassing fields such as neurology, psychiatry, dermatology, and neuroimaging will be instrumental in advancing our understanding of immune-related skin diseases. Furthermore, multi-omics approaches will enable a comprehensive exploration of the molecular mechanisms underlying these neural changes, facilitating the identification of novel diagnostic biomarkers and therapeutic targets.
皮肤作为人体最大的器官，是主要的物理屏障，在免疫防御过程中发挥着关键作用。免疫相关性皮肤病涵盖一系列复杂的皮肤病学病症，其特征为异常免疫反应，包括自身抗体的产生以及炎症介质的失调。越来越多的证据表明，免疫相关性皮肤病患者中合并神经精神疾病的患病率有所上升，这表明可能存在共同的发病机制。近年来，描绘复杂神经连接网络的脑连接组在阐明各种神经和精神疾病方面受到了广泛关注。研究人员已开始探究免疫相关性皮肤病患者的脑连接是否发生改变，从而从连接组角度来理解这些疾病的发病机制。本综述旨在综合和分析近期有关免疫相关性皮肤病的神经影像学研究，包括系统性红斑狼疮、银屑病、慢性自发性荨麻疹和特应性皮炎。我们主要讨论了与这些疾病相关的连接组研究，并总结了与其临床表现、进展和治疗相关的潜在机制。然后从我们的角度来看，我们认为涵盖神经学、精神病学、皮肤病学和神经影像学等领域的跨学科合作将有助于增进我们对免疫相关性皮肤病的理解。此外，多组学方法将能够全面探索这些神经变化背后的分子机制，有助于识别新的诊断生物标志物和治疗靶点。
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