Liu Yilong, Wang Ruoqi, Zhou Jinren, Lyu Qiang, Zhao Xiaoyong, Yang Xiaochun, Chen Kunsong, Gao Zhiwei, Li Xian
Zhejiang Key Laboratory of Horticultural Crop Quality Improvement, Zhejiang University, Hangzhou 310058, China.
Department of Vascular Surgery, the Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, China.
Food Funct. 2025 Mar 31;16(7):2737-2749. doi: 10.1039/d5fo00374a.
Atherosclerosis poses a significant threat to global health. This study aimed to investigate the effects of myricetin (MYR) on high-fat diet (HFD)-induced atherosclerosis in ApoE mice. Our findings demonstrated that MYR treatment significantly reduced the formation of atherosclerotic plaques, particularly at a high dose of 100 mg kg day. Additionally, MYR markedly attenuated lipid metabolism disorders in ApoE mice by decreasing body weight, improving serum lipid profiles, and reducing lipid deposition. Analysis of 16S rRNA sequencing revealed that MYR treatment enhanced the abundance of probiotic _, while it reduced that of obesity-associated genera, including and . Metabolomic analysis and RT-qPCR tests indicated that MYR upregulated hepatic bile acid biosynthesis, evidenced by increased total bile acid levels and enhanced expression of key enzymes CYP7A1 and CYP8B1, particularly through the classical biosynthetic pathway. Spearman's correlation analysis revealed strong associations between the regulated bile acids and these aforementioned bacteria. Therefore, our results demonstrated that MYR exerts an anti-atherosclerotic effect by modulating the gut-liver axis.
动脉粥样硬化对全球健康构成重大威胁。本研究旨在探讨杨梅素（MYR）对高脂饮食（HFD）诱导的ApoE小鼠动脉粥样硬化的影响。我们的研究结果表明，MYR治疗显著减少了动脉粥样硬化斑块的形成，尤其是在高剂量100 mg/kg/天的情况下。此外，MYR通过降低体重、改善血脂谱和减少脂质沉积，显著减轻了ApoE小鼠的脂质代谢紊乱。16S rRNA测序分析显示，MYR治疗增加了益生菌_的丰度，同时降低了与肥胖相关的菌属的丰度，包括_和_。代谢组学分析和RT-qPCR测试表明，MYR上调了肝脏胆汁酸生物合成，总胆汁酸水平升高以及关键酶CYP7A1和CYP8B1的表达增强证明了这一点，特别是通过经典生物合成途径。Spearman相关性分析揭示了受调节的胆汁酸与上述细菌之间的强关联。因此，我们的结果表明，MYR通过调节肠-肝轴发挥抗动脉粥样硬化作用。
