Kim Hyun Soo, Jung Jin Hyung, Han Kyungdo, Kim Hyewon, Jeon Hong Jin
Department of Psychiatry, Dong-A University College of Medicine, Busan, Republic of Korea.
Department of Biostatistics, College of Medicine, Catholic University of Korea, Seoul, Republic of Korea.
Front Psychiatry. 2025 Feb 21;16:1425637. doi: 10.3389/fpsyt.2025.1425637. eCollection 2025.
Despite a high tuberculosis incidence in Korea, the association between tuberculosis and depression remains underexplored. This study aims to assess depression risk in tuberculosis survivors.
Utilizing South Korea's National Health Insurance Sharing Service (NHISS) database, we conducted a gender-age-matched analysis comparing depression risk between tuberculosis survivors and the general population.
This study included 137,996 participants, of whom 34,499 had tuberculosis history, and 103,497 age- and sex-matched individuals were selected as the control group. The risk of developing depression was higher in tuberculosis survivors than in the control group (aHR 1.20, 95% CI 1.15-1.25). In men, the risk of developing depression was 1.32 times (95% CI 1.25-1.39) compared with 1.05 times (95% CI 0.98-1.12) in women. Those taking para-aminosalicylate, cycloserine, and prothionamide had a higher risk of developing depression compared to those using other anti-tuberculosis drugs, with the risk ratio ranging from 1.27 to 1.61.
Tuberculosis survivors had a higher risk of developing depression compared to the control group. Although the prevalence of depression was higher in women compared to men, the risk of developing depression was higher in male tuberculosis survivors than in the control group, in contrast to the findings in women. The risk of developing depression in tuberculosis survivors differed depending on the anti-tuberculosis drug used and was mainly high in most of the second-line anti-tuberculosis drugs.
尽管韩国结核病发病率较高，但结核病与抑郁症之间的关联仍未得到充分研究。本研究旨在评估结核病幸存者的抑郁风险。
利用韩国国民健康保险共享服务（NHISS）数据库，我们进行了一项性别年龄匹配分析，比较结核病幸存者与普通人群的抑郁风险。
本研究纳入了137,996名参与者，其中34,499人有结核病病史，103,497名年龄和性别匹配的个体被选为对照组。结核病幸存者患抑郁症的风险高于对照组（调整后风险比1.20，95%置信区间1.15 - 1.25）。在男性中，患抑郁症的风险是对照组的1.32倍（95%置信区间1.25 - 1.39），而女性为1.05倍（95%置信区间0.98 - 1.12）。与使用其他抗结核药物的人相比，服用对氨基水杨酸、环丝氨酸和丙硫异烟胺的人患抑郁症的风险更高，风险比在1.27至1.61之间。
与对照组相比，结核病幸存者患抑郁症的风险更高。尽管女性抑郁症患病率高于男性，但男性结核病幸存者患抑郁症的风险高于对照组，这与女性的研究结果相反。结核病幸存者患抑郁症的风险因使用的抗结核药物而异，主要在大多数二线抗结核药物使用者中风险较高。
