玻璃体内注射法西单抗治疗复发性葡萄膜炎性黄斑水肿。
Recurrent uveitic macular edema managed with intravitreal faricimab injection.
作者信息
Yavari Negin, Feky Dalia El, Anover Frances A, Nguyen Khiem, Mobasserian Azadeh, Nguyen Quan Dong, Or Christopher
机构信息
Spencer Center for Vision Research, Byers Eye Institute at Stanford University, 2452 Watson Court, Suite 200, 94303, Palo Alto, CA, USA.
出版信息
J Ophthalmic Inflamm Infect. 2025 Mar 13;15(1):25. doi: 10.1186/s12348-025-00478-6.
PURPOSE
To present a case of recurrent uveitic macular edema (UME) treated with intravitreal faricimab injection.
METHODS
Single case report from a tertiary referral center.
OBSERVATIONS
A 63-year-old Caucasian female presenting with recurrent UME due to birdshot chorioretinopathy (BSCR) in both eyes. UME had been treated with multiple agents including intravenous methylprednisone, posterior subtenons and intravitreal triamcinolone acetonide injection, dexamethasone implant, mycophenolate mofetil, and adalimumab with limited improvement and development of intolerance. Moreover, optical coherence tomography also revealed recurrence of UME with subretinal fluid in both eyes. After treatment with one dose of intravitreal faricimab injection, complete resolution of UME was achieved and maintained for three months.
CONCLUSION
The findings of this case hint towards the potential simultaneous effect of angiopoietin-2 blockade along with vascular endothelia growth factor A inhibition by faricimab in managing treatment-resistant UME. Nonetheless, more studies focusing on the role of intravitreal faricimab in UME are required.
目的
报告1例经玻璃体内注射法瑞西单抗治疗的复发性葡萄膜炎性黄斑水肿（UME）病例。
方法
来自三级转诊中心的单病例报告。
观察结果
一名63岁的白种女性，双眼因鸟枪弹样脉络膜视网膜病变（BSCR）出现复发性UME。UME曾接受多种治疗，包括静脉注射甲基强的松龙、球后注射和玻璃体内注射曲安奈德、地塞米松植入物、霉酚酸酯和阿达木单抗，但改善有限且出现不耐受情况。此外，光学相干断层扫描还显示双眼UME复发并伴有视网膜下液。经一剂玻璃体内注射法瑞西单抗治疗后，UME完全消退并维持了三个月。
结论
该病例的研究结果提示，法瑞西单抗在治疗难治性UME时，可能同时具有血管生成素-2阻断和血管内皮生长因子A抑制的作用。尽管如此，仍需要更多关于玻璃体内注射法瑞西单抗在UME中作用的研究。
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