Tan Joycelyn, Kunzmann Guy B, Virtue Sam, Cantor Jason R, Fazakerley Daniel J
Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK.
Morgridge Institute for Research, Madison, WI, USA; Department of Biochemistry, University of Wisconsin-Madison, Madison, WI, USA.
Cell Metab. 2025 Apr 1;37(4):802-805. doi: 10.1016/j.cmet.2025.01.027. Epub 2025 Mar 12.
The metabolic environment experienced by cultured cells often differs from physiological conditions. Here, we highlight the effects that the microenvironment can have on cultured cell behavior and advocate for researchers to re-evaluate culture practices to enhance the relevance and translational potential of in vitro studies.
培养细胞所经历的代谢环境通常与生理条件不同。在此，我们强调了微环境对培养细胞行为可能产生的影响，并主张研究人员重新评估培养方法，以提高体外研究的相关性和转化潜力。
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