Alves E Silva Thiago Luiz, Joseph Renuka Elizabeth, Vega-Rodriguez Joel
Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA.
Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA.
Curr Opin Insect Sci. 2025 Jun;69:101363. doi: 10.1016/j.cois.2025.101363. Epub 2025 Mar 11.
Mosquito blood feeding is complicated by the host's hemostatic and immune responses, which remain active after ingestion, affecting blood ingestion and digestion and threatening the midgut epithelium integrity. At the bite site, mosquitoes bypass the host's hemostatic and immune defenses by injecting saliva containing bioactive molecules, such as anticoagulants and immunomodulators, which facilitate efficient blood extraction. Ingested saliva can also modulate similar responses in the blood bolus. Here, we examine current evidence on how mosquito saliva proteins modulate blood responses in the midgut and enhance Plasmodium transmission. Saliva proteins are potential transmission-blocking targets for new intervention strategies to combat mosquito-borne diseases.
宿主的止血和免疫反应使蚊子吸食血液变得复杂，这些反应在吸血后仍保持活跃，影响血液的摄取和消化，并威胁中肠上皮的完整性。在叮咬部位，蚊子通过注入含有生物活性分子（如抗凝血剂和免疫调节剂）的唾液来绕过宿主的止血和免疫防御，从而促进高效吸血。摄入的唾液也可以调节血餐中的类似反应。在这里，我们研究了关于蚊子唾液蛋白如何调节中肠血液反应并增强疟原虫传播的现有证据。唾液蛋白是对抗蚊媒疾病的新干预策略潜在的传播阻断靶点。
