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《抗菌药物耐药机制:检测方法进展与临床意义》

Mechanisms of Antimicrobial Resistance in : Advances in Detection Methods and Clinical Implications.

作者信息

Li Jian, Shi Yuwen, Song Xuanli, Yin Xiaoyu, Liu Hui

机构信息

Department of Bacteria Disease, Jinan Center for Disease Control and Prevention, Jinan, Shandong, People's Republic of China.

出版信息

Infect Drug Resist. 2025 Mar 11;18:1339-1354. doi: 10.2147/IDR.S509016. eCollection 2025.

Abstract

. are ubiquitous gram-negative bacteria, commonly present in natural environments and as part of the human microbiota. is involved in the occurrence and development of many diseases, and effective antibiotics for it have attracted the attention of researchers. In recent years, its multi-drug resistance, particularly to carbapenems and β-lactam antibiotics, has posed significant challenges to clinical treatment. Therefore, a comprehensive understanding of the resistance mechanisms of , along with the enhancement of detection methods, is crucial for effectively controlling the spread of drug-resistant strains and guiding individualized clinical treatment. This paper systematically reviews the epidemiological characteristics, resistance mechanisms, detection methods, and treatment strategies of , aiming to provide new insights for the clinical management of this pathogen.

摘要

[具体细菌名称]是无处不在的革兰氏阴性菌,常见于自然环境中,也是人类微生物群的一部分。[具体细菌名称]与许多疾病的发生和发展有关,针对它的有效抗生素已引起研究人员的关注。近年来,它的多重耐药性,尤其是对碳青霉烯类和β-内酰胺类抗生素的耐药性,给临床治疗带来了重大挑战。因此,全面了解[具体细菌名称]的耐药机制以及改进检测方法,对于有效控制耐药菌株的传播和指导个体化临床治疗至关重要。本文系统综述了[具体细菌名称]的流行病学特征、耐药机制、检测方法和治疗策略,旨在为该病原体的临床管理提供新的见解。

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