颌骨1在G蛋白偶联受体（GPCR）刺激下通过肌醇三磷酸受体（ITPRs）加速钙信号的反应速度。

Jaw1 accelerates the reaction speed of the Ca signals via ITPRs upon GPCR stimulation.

作者信息

Kozono Takuma, Matsui Hitomi, Bandalan Marielle Fernandez, Tonozuka Takashi, Nishikawa Atsushi

机构信息

Smart-Core-Facility Promotion Organization, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu, Tokyo, 183-8509, Japan.

Department of Applied Biological Science, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu, Tokyo, 183-8509, Japan.

出版信息

Sci Rep. 2025 Mar 24;15(1):10104. doi: 10.1038/s41598-025-94489-x.

DOI:10.1038/s41598-025-94489-x

PMID:40128249

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11933412/

Abstract

Jaw1/LRMP/IRAG2 enhances Ca release via interaction with inositol 1,4,5-trisphosphate receptors (ITPRs), Ca channels on the endoplasmic reticulum, upon G protein-coupled receptor stimulation. While our previous works demonstrated the increases in the maximum amplitude and retention time of the Ca curve with heterogeneous effects on each ITPR subtype: ITPR1, ITPR2, and ITPR3, the effects on the reaction speed remain unclear. In this study, we unveiled the additional roles of Jaw1 in accelerating the signal onset time and rise time to the first peak top, especially in the cells expressing ITPR1. These findings shed more light on the relationship between the expression pattern of Jaw1 and ITPRs, and the heterogeneous pattern of the Ca dynamics, offering insights into their physiological implications.

摘要

Jaw1/LRMP/IRAG2通过与1,4,5-三磷酸肌醇受体（ITPRs，内质网上的钙通道）相互作用，在G蛋白偶联受体刺激后增强钙释放。虽然我们之前的研究表明，钙曲线的最大振幅和保留时间增加，对每种ITPR亚型（ITPR1、ITPR2和ITPR3）有不同影响，但对反应速度的影响仍不清楚。在本研究中，我们揭示了Jaw1在加速信号起始时间和上升到第一个峰值顶部的时间方面的额外作用，特别是在表达ITPR1的细胞中。这些发现进一步阐明了Jaw1与ITPRs的表达模式以及钙动力学的异质性模式之间的关系，为它们的生理意义提供了见解。