Mohamed Alaa S, Jahani Neesha, Li Mingyu, Shah Manan, Bruno Askiel, Singh Dilip
Neurology, Augusta University, Augusta, USA.
Neurology, Augusta University Medical College of Georgia, Augusta, USA.
Cureus. 2025 Feb 23;17(2):e79517. doi: 10.7759/cureus.79517. eCollection 2025 Feb.
There has been a multitude of neurological sequelae associated with the 2019 SARS-CoV-2 outbreak. We describe a unique case of a 31-year-old individual who developed post-infectious autoimmune rhombencephalitis approximately two weeks after testing positive for coronavirus disease 2019 (COVID-19). Treatment with high-dose corticosteroids with four weeks of taper resulted in excellent clinical recovery without any relapse. Thus, our findings support the use of immunotherapy as a potential treatment in cases of post-COVID-19 autoimmune rhombencephalitis. Furthermore, this case highlights the importance of considering post-infectious COVID-19 sequelae as a differential diagnosis in patients presenting with rhombencephalitis in the appropriate clinical setting.
2019年严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)疫情引发了众多神经系统后遗症。我们描述了一例独特病例,一名31岁个体在新型冠状病毒肺炎(COVID-19)检测呈阳性约两周后患上感染后自身免疫性菱形脑炎。采用大剂量皮质类固醇治疗并逐渐减量四周后,临床恢复良好,未出现任何复发情况。因此,我们的研究结果支持将免疫疗法作为COVID-19后自身免疫性菱形脑炎病例的一种潜在治疗方法。此外,该病例凸显了在适当临床环境下,对于出现菱形脑炎的患者,将感染后COVID-19后遗症作为鉴别诊断的重要性。