免疫抑制患者中的乙肝病毒再激活：筛查、预防及管理，包括实体器官移植受者
HBV Reactivation in Immunosuppressed Patients: Screening, Prevention, and Management Including Solid Organ Transplant Recipients.
作者信息
Vutien Philip, Nguyen Mindie H
机构信息
Division of Gastroenterology and Hepatology, University of Washington Medical Center, 1959 NE Pacific Street, Box 356175, Seattle, WA 98195, USA.
Division of Gastroenterology and Hepatology, Stanford University Medical Center, Palo Alto, CA 94305, USA.
出版信息
Viruses. 2025 Mar 9;17(3):388. doi: 10.3390/v17030388.
Hepatitis B virus (HBV) infection remains a global health challenge, affecting over 254 million individuals chronically and contributing significantly to cirrhosis, liver failure, and hepatocellular carcinoma. Despite advancements in antiviral therapy, HBV reactivation remains a critical concern, particularly in immunosuppressed individuals, including non-transplant patients undergoing immunosuppressive therapy and solid organ transplant recipients. This review provides screening and management strategies for HBV reactivation in these populations.
乙型肝炎病毒（HBV）感染仍然是一项全球性的健康挑战，慢性感染超过2.54亿人，并在肝硬化、肝衰竭和肝细胞癌的发病中起到重要作用。尽管抗病毒治疗取得了进展，但HBV再激活仍然是一个关键问题，尤其是在免疫抑制人群中，包括接受免疫抑制治疗的非移植患者和实体器官移植受者。本综述提供了这些人群中HBV再激活的筛查和管理策略。
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