Taxing Hearts: Loss Stirs Up TRPV4 Channels in Arrhythmogenic Cardiomyopathy.
作者信息
Ratnavadivel Sandra, Jreije Afaf, Sheikh Farah
机构信息
Department of Medicine, University of California San Diego, La Jolla, CA.
出版信息
Circ Res. 2025 Mar 28;136(7):685-687. doi: 10.1161/CIRCRESAHA.124.325502. Epub 2025 Mar 27.
Abstract
摘要
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Taxing Hearts: Loss Stirs Up TRPV4 Channels in Arrhythmogenic Cardiomyopathy.给心脏增加负担：在致心律失常性心肌病中，损伤会激活瞬时受体电位香草酸亚型4（TRPV4）通道
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本文引用的文献
1
Causes TRPV4-Mediated Autosomal Recessive Arrhythmogenic Cardiomyopathy.导致TRPV4介导的常染色体隐性致心律失常性心肌病。
Circ Res. 2025 Mar 28;136(7):667-684. doi: 10.1161/CIRCRESAHA.124.325180. Epub 2025 Feb 18.
2
Plakophilin 2 gene therapy prevents and rescues arrhythmogenic right ventricular cardiomyopathy in a mouse model harboring patient genetics.桥粒斑蛋白 2 基因治疗可预防和挽救携带患者遗传基因的小鼠模型中的心律失常性右室心肌病。
Nat Cardiovasc Res. 2023 Dec;2(12):1246-1261. doi: 10.1038/s44161-023-00370-3. Epub 2023 Dec 7.
3
Arrhythmogenic Right Ventricular Cardiomyopathy in Children: A Systematic Review.儿童致心律失常性右室心肌病：一项系统评价
Diagnostics (Basel). 2024 Jan 12;14(2):175. doi: 10.3390/diagnostics14020175.
4
Desmosomes: emerging pathways and non-canonical functions in cardiac arrhythmias and disease.桥粒：心律失常和疾病中的新兴途径及非经典功能
Biophys Rev. 2021 Sep 4;13(5):697-706. doi: 10.1007/s12551-021-00829-2. eCollection 2021 Oct.
5
International Evidence Based Reappraisal of Genes Associated With Arrhythmogenic Right Ventricular Cardiomyopathy Using the Clinical Genome Resource Framework.利用临床基因组资源框架对心律失常性右心室心肌病相关基因进行国际循证再评估。
Circ Genom Precis Med. 2021 Jun;14(3):e003273. doi: 10.1161/CIRCGEN.120.003273. Epub 2021 Apr 8.
6
Arrhythmogenic Right Ventricular Cardiomyopathy-Associated Desmosomal Variants Are Rarely De Novo.致心律失常性右心室心肌病相关桥粒变异很少是新生的。
Circ Genom Precis Med. 2019 Aug;12(8):e002467. doi: 10.1161/CIRCGEN.119.002467. Epub 2019 Aug 6.
7
The TRPV4 Agonist GSK1016790A Regulates the Membrane Expression of TRPV4 Channels.TRPV4激动剂GSK1016790A调节TRPV4通道的膜表达。
Front Pharmacol. 2019 Jan 23;10:6. doi: 10.3389/fphar.2019.00006. eCollection 2019.
8
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Cardiovasc Res. 2019 Jan 1;115(1):46-56. doi: 10.1093/cvr/cvy156.
9
Calcium Signaling and Cardiac Arrhythmias.钙信号与心律失常
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