Sutar Prerna, Pethe Atharv, Kumar Piyush, Tripathi Divya, Maity Dipak
School of Health Sciences and Technology, UPES, Bidholi Campus, Dehradun 248007, Uttarakhand, India.
Integrated Nanosystems Development Institute, Indiana University Indianapolis, Indianapolis, IN 46202, USA.
Bioengineering (Basel). 2025 Mar 3;12(3):254. doi: 10.3390/bioengineering12030254.
Pancreatitis is a prominent and severe type of inflammatory disorder that has grabbed a lot of scientific and clinical interest to prevent its onset. It should be detected early to avoid the development of serious complications, which occur due to long-term damage to the pancreas. The accurate measurement of biomarkers that are released from the pancreas during inflammation is essential for the detection and early treatment of patients with severe acute and chronic pancreatitis, but this is sub-optimally performed in clinically relevant practices, mainly due to the complexity of the procedure and the cost of the treatment. Clinically available tests for the early detection of pancreatitis are often time-consuming. The early detection of pancreatitis also relates to disorders of the exocrine pancreas, such as cystic fibrosis in the hereditary form and cystic fibrosis-like syndrome in the acquired form of pancreatitis, which are genetic disorders with symptoms that can be correlated with the overexpression of specific markers such as creatinine in biological fluids like urine. In this review, we studied how to develop a minimally invasive system using hydrogel-based biosensors, which are highly absorbent and biocompatible polymers that can respond to specific stimuli such as enzymes, pH, temperature, or the presence of biomarkers. These biosensors are helpful for real-time health monitoring and medical diagnostics since they translate biological reactions into quantifiable data. This paper also sheds light on the possible use of Ayurvedic formulations along with hydrogels as a treatment strategy. These analytical devices can be used to enhance the early detection of severe pancreatitis in real time.
胰腺炎是一种突出且严重的炎症性疾病，为预防其发作已引发了大量科学和临床关注。应尽早检测出胰腺炎，以避免因胰腺长期受损而引发严重并发症。准确测量炎症期间胰腺释放的生物标志物对于严重急性和慢性胰腺炎患者的检测和早期治疗至关重要，但在临床相关实践中，这一操作的效果并不理想，主要原因是该过程复杂且治疗成本高。临床上用于早期检测胰腺炎的现有检测方法往往耗时较长。胰腺炎的早期检测还与外分泌性胰腺疾病有关，例如遗传性形式的囊性纤维化以及获得性胰腺炎形式的囊性纤维化样综合征，这些都是遗传性疾病，其症状可与生物体液（如尿液）中肌酐等特定标志物的过表达相关。在本综述中，我们研究了如何利用基于水凝胶的生物传感器开发一种微创系统，水凝胶是一种高吸水性且具有生物相容性的聚合物，能够对酶、pH值、温度或生物标志物的存在等特定刺激做出反应。这些生物传感器有助于实时健康监测和医学诊断，因为它们能将生物反应转化为可量化的数据。本文还阐明了阿育吠陀配方与水凝胶一起作为治疗策略的可能用途。这些分析设备可用于加强对严重胰腺炎的实时早期检测。
