Li Ruimiao, Ren Mingyu, Liu Limin, Zhang Ruina, Guo Wensheng
Department of Orbital Disease and Ocular Tumor, Hebei Eye Hospital, Xingtai, Hebei, China.
Department of Ophthalmology, the 940 Hospital of Joint Service Support Forces of the Chinese People's Liberation Army, Lanzhou, China.
Medicine (Baltimore). 2025 Jan 3;104(1):e41205. doi: 10.1097/MD.0000000000041205.
Orbital teratoma is a relatively rare disease in infancy. In the pediatric population undergoing significant growth and development, the presence of giant orbital masses can significantly affect orbital volumes and impair the visual function. Traditional treatments may not yield anticipated effectiveness, often leading to numerous complications. This report aims to present a rare case involving a giant orbital intraconal teratoma. The objective is to analyze the treatment course comprehensively, distill valuable experiences and lessons learned, enhance treatment strategies, and ultimately reduce the incidence of complications associated with these formidable pediatric tumors.
A 2-year-old female child was presented exhibiting proptosis and inward and upward eyeball displacement. Enhanced magnetic resonance imaging revealed a well-circumscribed mass, persisting with hypointense signals on T1-weighted images (T1WI) and hyperintense signals on T2-weighted images (T2WI).
The diagnosis of teratoma was confirmed finally through histological and immunohistochemical exams.
A transconjunctival approach via the inferior fornix, coupled with canthotomy and cantholysis, was performed. However, a month postsurgery, the patient developed enophthalmos, conjunctival hyperemia, and keratitis upon ocular examination. A second operation involved the implantation of allogeneic sclera into the orbit to increase orbital volume, improve the pitting of the fossa, and restore keratitis to normal.
No recurrence and other complications were noted during the 1-year follow-up.
Giant orbital teratomas in children are infrequent and pose significant challenges in the field of therapy. The potential consequences of larger orbital masses in childhood, including increased orbital volume and the risk of postoperative enophthalmos and keratitis. The findings emphasize the importance of timely implantation into the orbital after mass excision to enhance orbital volume and reduce the incidence of complications.
眼眶畸胎瘤在婴儿期是一种相对罕见的疾病。在经历显著生长发育的儿科人群中,巨大眼眶肿块的存在会显著影响眼眶容积并损害视觉功能。传统治疗可能无法产生预期效果,常常导致众多并发症。本报告旨在呈现一例涉及巨大眼眶圆锥内畸胎瘤的罕见病例。目的是全面分析治疗过程,提炼宝贵经验和教训,改进治疗策略,并最终降低与这些棘手儿科肿瘤相关的并发症发生率。
一名2岁女童出现眼球突出以及眼球向内和向上移位。增强磁共振成像显示一个边界清晰的肿块,在T1加权像(T1WI)上呈低信号,在T2加权像(T2WI)上呈高信号。
最终通过组织学和免疫组化检查确诊为畸胎瘤。
经下穹窿结膜入路,联合内眦切开和眦松解术。然而,术后1个月眼部检查时,患者出现眼球内陷、结膜充血和角膜炎。第二次手术是将异体巩膜植入眼眶以增加眼眶容积,改善眶窝凹陷,并使角膜炎恢复正常。
在1年随访期间未发现复发及其他并发症。
儿童巨大眼眶畸胎瘤罕见,在治疗领域构成重大挑战。儿童期较大眼眶肿块的潜在后果,包括眼眶容积增加以及术后眼球内陷和角膜炎的风险。这些发现强调了在肿块切除后及时植入眼眶以增加眼眶容积并降低并发症发生率的重要性。