Wang Yiqin, Li Yongqiang, Lin Yong, Cao Chuangyu, Chen Dongcheng, Huang Xianguang, Li Canhua, Xu Haoming, Lai Huasheng, Chen Huiting, Zhou Yongjian
Department of Gastroenterology and Hepatology, The Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou, China.
Department of Gastroenterology and Hepatology, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, China.
Cell Death Discov. 2025 Apr 4;11(1):140. doi: 10.1038/s41420-025-02413-z.
Hepatocellular carcinoma (HCC) is closely linked to alterations in the gut microbiota. This dysbiosis is characterized by significant changes in the microbial population, which correlate with the progression of HCC. Gut dysbiosis ultimately promotes HCC development in several ways: it damages the integrity of the gut-vascular barrier (GVB), alters the tumor microenvironment (TME), and even affects the intratumoral microbiota. Subsequently, intratumoral microbiota present a characteristic profile and play an essential role in HCC progression mainly by causing DNA damage, mediating tumor-related signaling pathways, altering the TME, promoting HCC metastasis, or through other mechanisms. Both gut microbiota and intratumoral microbiota have dual effects on HCC progression; a comprehensive understanding of their complex biological roles will provide a theoretical foundation for potential clinical applications in HCC treatment.
肝细胞癌（HCC）与肠道微生物群的改变密切相关。这种生态失调的特征是微生物种群的显著变化，这与HCC的进展相关。肠道生态失调最终通过多种方式促进HCC的发展：它损害肠道血管屏障（GVB）的完整性，改变肿瘤微环境（TME），甚至影响肿瘤内微生物群。随后，肿瘤内微生物群呈现出特征性特征，并主要通过引起DNA损伤、介导肿瘤相关信号通路、改变TME、促进HCC转移或通过其他机制在HCC进展中发挥重要作用。肠道微生物群和肿瘤内微生物群对HCC进展都有双重影响；全面了解它们复杂的生物学作用将为HCC治疗的潜在临床应用提供理论基础。
Zotero 插件
