通过硼二吡咯·杯[7]配合物追踪细胞中的主客体识别。

Tracking host-guest recognition in cells by a BODIPY·CB[7] complex.

作者信息

Liu Fengbo, Xiao Haiqi, Gao Quan, Siri Didier, Bardelang David, Xing Qi, Geng Jing

机构信息

Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518059, China.

Aix-Marseille Universite, CNRS, Institut de Chimie Radicalaire, UMR 7273, 13397 Marseille, France.

出版信息

Chem Commun (Camb). 2025 Apr 29;61(36):6675-6678. doi: 10.1039/d5cc00663e.

DOI:10.1039/d5cc00663e

PMID:40200752

Abstract

Interested in host·guest binding events in cellular environments, intracellular recognition between fluorescent BODIPY and cucurbit[7]uril was explored for lysosome tracking in living cancer cells. Sequential deaggregation from spontaneously dimerized BODIPY was unusually discovered upon complexation with CB[7].

摘要

由于对细胞环境中的主客体结合事件感兴趣，研究了荧光硼二吡咯（BODIPY）与葫芦[7]脲（CB[7]）之间的细胞内识别，用于活癌细胞中的溶酶体追踪。与CB[7]络合后，意外地发现自发二聚化的BODIPY发生了顺序解聚。