新型α-淀粉酶阻滞剂7,8-二羟基香豆素（瑞香素）的毒性及抗淀粉酶活性评估
Evaluation of toxicity and anti-amylase activity of 7, 8 dihydroxy coumarin (Daphnetin), a novel α-amylase blocker and .
作者信息
Kar Sayan, Dutta Sagnik, Saha Shraddha, Sarkar Kasturi, Chatterjee Shreya, Giri Nabanita, Sil Parames C
机构信息
Department of Microbiology St. Xavier's College, Kolkata, India.
Department of Microbiology, University of Calcutta, India.
出版信息
Toxicol Rep. 2025 Mar 15;14:101991. doi: 10.1016/j.toxrep.2025.101991. eCollection 2025 Jun.
Management of postprandial blood glucose is a measure in regulating the blood sugar concentration. This paper evaluates the anti-amylase property of a natural compound 7,8 dihydroxycoumarin (daphnetin) both and . The inhibitory effect of daphnetin was evaluated against salivary (HSA) and pancreatic α-amylases (PPA) and α-glucosidase (AG) . Enzyme kinetics studies revealed that the inhibition of HSA, PPA and AG by daphnetin was competitive in nature. Pretreatment with daphnetin was found to inhibit the amylases as confirmed by the oral starch tolerance test (OSTT). No adverse effect of daphnetin was observed on serum markers and organs like liver, kidney and small intestine. The impact of the inhibitory effect of daphnetin in was comparable to the positive control, acarbose in all aspects.
餐后血糖管理是调节血糖浓度的一项措施。本文评估了天然化合物7,8-二羟基香豆素（瑞香素）对唾液淀粉酶（HSA）、胰腺α-淀粉酶（PPA）和α-葡萄糖苷酶（AG）的抗淀粉酶特性。酶动力学研究表明，瑞香素对HSA、PPA和AG的抑制作用本质上是竞争性的。口服淀粉耐量试验（OSTT）证实，瑞香素预处理可抑制淀粉酶。未观察到瑞香素对血清标志物以及肝脏、肾脏和小肠等器官有不良影响。瑞香素的抑制作用在各方面与阳性对照阿卡波糖相当。
Zotero 插件