Mai Sabrina, Murphy Allison J, Hasse J Michael, Briggs Farran
Neuroscience Graduate Program, University of Rochester, Rochester, NY, 14642, USA.
Department of Neuroscience, University of Rochester School of Medicine, Rochester, NY, 14642, USA.
Nat Commun. 2025 Apr 9;16(1):3380. doi: 10.1038/s41467-025-58667-9.
Sensory circuits are organized in parallel, e.g. parallel streams relay feedforward visual information from retina to cortex. Corticogeniculate (CG) feedback is also organized in parallel; however, stream-specific influences of CG feedback remained unresolved. We utilized optogenetics to manipulate CG feedback in monkeys while recording geniculate responses to a comprehensive set of visual stimuli designed to probe stream-specific responses. Here we show that CG feedback improved the spatial resolution of magnocellular, but not parvocellular neurons. Optogenetically enhancing CG feedback increased extraclassical surround suppression, shrunk classical receptive fields, and increased preferred spatial frequencies among magnocellular neurons. Optogenetically suppressing CG feedback reduced surround suppression. Enhancing CG feedback in female ferrets revealed similar stream-specific effects in geniculate Y, but not X neurons. Furthermore, optogenetically enhancing CG feedback improved temporal response precision across neuronal types. These results support dual functional roles for CG feedback in enhancing spatial resolution in a stream-specific manner and improving temporal precision broadly.
感觉神经回路以并行方式组织，例如并行信息流从前庭将视觉信息从视网膜传递到皮层。皮质膝状体（CG）反馈也以并行方式组织；然而，CG反馈的特定信息流影响仍未得到解决。我们利用光遗传学在猴子中操纵CG反馈，同时记录膝状体对一组全面的视觉刺激的反应，这些刺激旨在探测特定信息流的反应。在这里，我们表明CG反馈提高了大细胞神经元而非小细胞神经元的空间分辨率。通过光遗传学增强CG反馈增加了超经典环绕抑制，缩小了经典感受野，并增加了大细胞神经元中的偏好空间频率。通过光遗传学抑制CG反馈减少了环绕抑制。在雌性雪貂中增强CG反馈在膝状体Y神经元而非X神经元中显示出类似的特定信息流效应。此外，通过光遗传学增强CG反馈提高了所有神经元类型的时间反应精度。这些结果支持CG反馈在以特定信息流方式提高空间分辨率和广泛提高时间精度方面的双重功能作用。
