Advanced Materials for Biological Field-Effect Transistors (Bio-FETs) in Precision Healthcare and Biosensing.

Biological Field Effect Transistors (Bio-FETs) are redefining the standard of biosensing by enabling label-free, real-time, and extremely sensitive detection of biomolecules. At the center of this innovation is the fundamental empowering role of advanced materials, such as graphene, molybdenum disulfide, carbon nanotubes, and silicon. These materials, when harnessed with the downstream biomolecular probes like aptamers, antibodies, and enzymes, allow Bio-FETs to offer unrivaled sensitivity and precision. This review is an exposition of how advancements in materials science have permitted Bio-FETs to detect biomarkers in extremely low concentrations, from femtomolar to attomolar levels, ensuring device stability and reliability. Specifically, the review examines how the incorporation of cutting-edge materials architectures, like flexible / stretchable and multiplexed designs, is expanding the frontiers of biosensing and contributing to the development of more adaptable and user-friendly Bio-FET platforms. A key focus is placed on the synergy of Bio-FETs with artificial intelligence (AI), the Internet of Things (IoT), and sustainable materials approaches as fast-tracking toward transition from research into practical healthcare applications. The review also explores current challenges such as material reproducibility, operational durability, and cost-effectiveness. It outlines targeted strategies to address these hurdles and facilitate scalable manufacturing. By emphasizing the transformative role played by advanced materials and their cementing position in Bio-FETs, this review positions Bio-FETs as a cornerstone technology for the future healthcare solution for precision applications. These advancements would lead to an era where material innovation would herald massive strides in biomedical diagnostics and subsume.