Liang Zhuming, Mo Yanan, Zhang Yujiao, Yu Yanjing, Ji Yinan
Department of Breast Surgery, The Affliated Tumor Hospital of Guangxi Medical University, Nanning, Guangxi, China.
Front Pharmacol. 2025 Mar 27;16:1585668. doi: 10.3389/fphar.2025.1585668. eCollection 2025.
Brain metastasis in breast cancer (BCBM) significantly threatens the survival and quality of life of patients, particularly those with triple-negative (TNBC) and HER2-positive subtypes. It involves complex molecular mechanisms and diverse signaling pathways. This review highlights recent research on the molecular mechanisms and signaling pathways of BCBM. The process of BCBM includes several key steps: local infiltration of cancer cells into the bloodstream and subsequent spread to the brain. They must then overcome the blood-brain barrier (BBB) to establish and grow in the brain. Multiple signaling pathways, including PI3K/AKT, STAT3, NF-κB, Notch, and Wnt are involved in this process. Overall, BCBM is a complex disease regulated by multiple molecular mechanisms and signaling pathways. To improve patient survival and quality of life, it is crucial to deepen research into the mechanisms of BCBM and explore new treatment targets and strategies. This will enhance our understanding of BCBM and lead to more effective treatments.
乳腺癌脑转移（BCBM）严重威胁患者的生存和生活质量，尤其是三阴性（TNBC）和HER2阳性亚型患者。它涉及复杂的分子机制和多样的信号通路。本综述重点介绍了BCBM分子机制和信号通路的最新研究。BCBM过程包括几个关键步骤：癌细胞局部浸润进入血流，随后扩散至脑。然后它们必须克服血脑屏障（BBB）才能在脑中定植和生长。包括PI3K/AKT、STAT3、NF-κB、Notch和Wnt在内的多种信号通路参与了这一过程。总体而言，BCBM是一种受多种分子机制和信号通路调控的复杂疾病。为提高患者的生存和生活质量，深入研究BCBM的机制并探索新的治疗靶点和策略至关重要。这将增进我们对BCBM的理解，并带来更有效的治疗方法。
Zotero 插件