Multifunctional applications of silk fibroin in biomedical engineering: A comprehensive review on innovations and impact.

Silk fibroin (SF) is a biomaterial naturally produced by certain insects (notably silkworms), animals such as spiders, or through recombinant methods in genetically modified organisms. Its exceptional mechanical properties, biocompatibility, degradability, and bioactivity have inspired extensive research. In biomedicine, SF has been utilized in various forms, including gels, membranes, microspheres, and more. It also demonstrates versatility for applications across medical devices, regenerative medicine, tissue engineering, and related fields. This review explores the current research status, advantages, limitations, and potential application pathways of SF in biomedical engineering. The objective is to stimulate innovative ideas and perspectives for research and applications involving silk.