经瓣膜机械循环支持可使绵羊模型中的缺血性慢性衰竭心脏发生逆向重塑。
Transvalvular Mechanical Circulatory Support Reverse Remodels the Ischemic Chronic Failing Heart in an Ovine Model.
作者信息
Meyns Bart, Parks Randi J, Verbeken Erik, van Hecke Manon, Jacobs Steven, Sikole Magdalena, Van Edom Charlotte, Bennek Schoepping Eveline, Claus Piet
机构信息
Department Cardiac Surgery, KULeuven, Leuven, Belgium.
Academic and Pre-Clinical Research, Abiomed, Inc, Aachen, Germany.
出版信息
JACC Basic Transl Sci. 2025 Jul;10(7):101221. doi: 10.1016/j.jacbts.2025.01.003. Epub 2025 Mar 19.
Sixteen sheep with ischemic chronic heart failure were randomized to either 3 months of Impella 5.5 support (Abiomed) or sham. Myocardial reverse remodeling by Impella support was shown by a significant reduction of end-diastolic volume (Impella 22% reduction, and control 5% increase; P = 0.011) and end-systolic volume (Impella 20% reduction, and control 11% increase; P = 0.011). Functional measurements demonstrated improved regional ejection fraction and wall thickening in the viable myocardium of hearts supported with Impella. Supported animals had a significant decrease in wall volume, with less cardiomyocyte hypertrophy than control subjects.
16只患有缺血性慢性心力衰竭的绵羊被随机分为两组，分别接受3个月的Impella 5.5支持治疗（Abiomed公司）或假手术。Impella支持治疗可使心肌发生逆向重构，表现为舒张末期容积显著降低（Impella组降低22%，对照组增加5%；P = 0.011）和收缩末期容积显著降低（Impella组降低20%，对照组增加11%；P = 0.011）。功能测量结果显示，接受Impella支持治疗的心脏存活心肌区域的射血分数和心肌增厚得到改善。接受支持治疗的动物心肌壁容积显著减小，心肌细胞肥大程度低于对照组。
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