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Clarifying the GDF15-LTL relationship: The role of medications, lifestyle, and morbidity.阐明生长分化因子15（GDF15）与端粒长度（LTL）的关系：药物、生活方式和发病率的作用。
J Nutr Health Aging. 2025 May;29(5):100558. doi: 10.1016/j.jnha.2025.100558. Epub 2025 Apr 14.
2
Serum Growth Differentiation Factor 15 is Negatively Associated with Leukocyte Telomere Length.血清生长分化因子15与白细胞端粒长度呈负相关。
J Nutr Health Aging. 2025 Apr;29(4):100493. doi: 10.1016/j.jnha.2025.100493. Epub 2025 Feb 3.
3
Overexpression of Growth Differentiation Factor 15 Reduces Neuronal Cell Damage Induced by Oxygen-Glucose Deprivation/Reoxygenation via Inhibiting Endoplasmic Reticulum Stress-Mediated Ferroptosis.生长分化因子15的过表达通过抑制内质网应激介导的铁死亡减少氧糖剥夺/复氧诱导的神经元细胞损伤。
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Role and prognostic value of growth differentiation factor 15 in patient of heart failure with preserved ejection fraction: insights from the PURSUIT-HFpEF registry.生长分化因子15在射血分数保留的心力衰竭患者中的作用及预后价值：来自PURSUIT-HFpEF注册研究的见解
Open Heart. 2025 Jan 19;12(1):e003008. doi: 10.1136/openhrt-2024-003008.
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Diagnostic utility of GDF15 in neurodegenerative diseases: A systematic review and meta-analysis.GDF15 在神经退行性疾病中的诊断效用：系统评价和荟萃分析。
Brain Behav. 2022 Feb;12(2):e2502. doi: 10.1002/brb3.2502. Epub 2022 Jan 24.
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Ectopic expression of GDF15 in cancer-associated fibroblasts enhances melanoma immunosuppression via the GFRAL/RET cascade.癌症相关成纤维细胞中GDF15的异位表达通过GFRAL/RET级联增强黑色素瘤免疫抑制。
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Association of life's essential 8 with leukocyte telomere length and mitochondrial DNA copy number: Findings from the population-based UK Biobank study.生命必需8项与白细胞端粒长度及线粒体DNA拷贝数的关联：基于人群的英国生物银行研究结果
J Nutr Health Aging. 2025 Apr 17;29(7):100557. doi: 10.1016/j.jnha.2025.100557.
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Association between leucocyte telomere length and the risk of atrial fibrillation: An updated systematic review and meta-analysis.白细胞端粒长度与心房颤动风险的关系：一项更新的系统评价和荟萃分析。
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Relevance of GDF15 as a biomarker for clinical outcomes after bariatric surgery.生长分化因子15作为减肥手术后临床结局生物标志物的相关性。
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Shorter telomere length in Europeans than in Africans due to polygenetic adaptation.由于多基因适应，欧洲人的端粒长度比非洲人短。
Hum Mol Genet. 2016 Jun 1;25(11):2324-2330. doi: 10.1093/hmg/ddw070. Epub 2016 Mar 2.

本文引用的文献

1
Serum Growth Differentiation Factor 15 is Negatively Associated with Leukocyte Telomere Length.血清生长分化因子15与白细胞端粒长度呈负相关。
J Nutr Health Aging. 2025 Apr;29(4):100493. doi: 10.1016/j.jnha.2025.100493. Epub 2025 Feb 3.
2
Bitter-tasting drugs tune GDF15 and GLP-1 expression via bitter taste or motilin receptors in the intestine of patients with obesity.苦味药物通过肥胖患者肠道中的苦味受体或胃动素受体调节 GDF15 和 GLP-1 的表达。
Mol Metab. 2024 Oct;88:102002. doi: 10.1016/j.molmet.2024.102002. Epub 2024 Aug 5.
3
Longitudinal course of GDF15 levels before acute hospitalization and death in the general population.一般人群中急性住院前和死亡前 GDF15 水平的纵向病程。
Geroscience. 2021 Aug;43(4):1835-1849. doi: 10.1007/s11357-021-00359-5. Epub 2021 Mar 24.
4
GDF15 mediates the effects of metformin on body weight and energy balance.GDF15 介导二甲双胍对体重和能量平衡的影响。
Nature. 2020 Feb;578(7795):444-448. doi: 10.1038/s41586-019-1911-y. Epub 2019 Dec 25.
5
A study of biological and lifestyle factors, including within-subject variation, affecting concentrations of growth differentiation factor 15 in serum.一项研究生物和生活方式因素，包括个体内变异，对血清中生长分化因子 15 浓度的影响。
Clin Chem Lab Med. 2019 Jun 26;57(7):1035-1043. doi: 10.1515/cclm-2018-0908.

Clarifying the GDF15-LTL relationship: The role of medications, lifestyle, and morbidity.

作者信息

Chao Chia-Ter

机构信息

Department of Internal Medicine, Min-Sheng General Hospital, Taoyuan City, Taiwan; Division of Nephrology, Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan; Graduate Institute of Toxicology, National Taiwan University College of Medicine, Taipei, Taiwan; Graduate Institute of Medical Education and Bioethics, National Taiwan University College of Medicine, Taipei, Taiwan.

出版信息

J Nutr Health Aging. 2025 May;29(5):100558. doi: 10.1016/j.jnha.2025.100558. Epub 2025 Apr 14.

DOI:10.1016/j.jnha.2025.100558
PMID:40233440
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12180001/
Abstract
摘要