Huang Le, Xu Kailing, Yang Qingping, Ding Zijun, Shao Zhenduo, Li Enliang
Department of General Surgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, 1 Minde Road, Nanchang, 330006, China.
HuanKui Academy, Nanchang University, Nanchang, 330006, Jiangxi, China.
Cell Death Discov. 2025 Apr 15;11(1):174. doi: 10.1038/s41420-025-02469-x.
Annexin A2 (ANXA2) is a multifunctional protein that binds to calcium and phospholipids and plays a critical role in various pathological conditions, including cancer and inflammation. Recently, there has been increasing recognition of the significant role of ANXA2 in inhibiting apoptosis and promoting immune evasion in tumour cells. Therefore, a deep understanding of the regulatory mechanisms of ANXA2 in tumour cell apoptosis and its relationship with immune evasion can provide new targets for cancer therapy. This review summarizes the role and mechanisms of ANXA2 in regulating apoptosis in tumour cells, the connection between apoptosis regulation and tumour immunity, and the potential role of ANXA2 in therapy resistance.
膜联蛋白A2（ANXA2）是一种多功能蛋白，可与钙和磷脂结合，并在包括癌症和炎症在内的各种病理状况中发挥关键作用。最近，人们越来越认识到ANXA2在抑制肿瘤细胞凋亡和促进免疫逃逸方面的重要作用。因此，深入了解ANXA2在肿瘤细胞凋亡中的调控机制及其与免疫逃逸的关系可为癌症治疗提供新的靶点。本综述总结了ANXA2在调节肿瘤细胞凋亡中的作用和机制、凋亡调节与肿瘤免疫之间的联系，以及ANXA2在治疗耐药性中的潜在作用。
