Tang Lin-Feng, Tang Feng-Ling, Zhou Hao, Li Ze-Kun, Pi Chao-Qun, He Yang, Li Ming
State Key Laboratory of Radiation Medicine and Protection, Key Laboratory of Radiation Damage and Treatment of Jiangsu Provincial Universities and Colleges, Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, School of Radiation Medicine and Protection, Suzhou Medical College, Soochow University, Suzhou, China.
Department of Pathology, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Mol Nutr Food Res. 2025 Jun;69(11):e70057. doi: 10.1002/mnfr.70057. Epub 2025 Apr 17.
The gastrointestinal tract is highly sensitive to ionizing radiation (IR), which causes radiation-induced intestinal injury (RIII). There are no effective drugs available for RIII in routine clinical treatment, which is a major limiting factor during the process of radiotherapy for pelvic abdominal malignancies. In this study, we aimed to elucidate the potential of probiotic Bacillus coagulans BC99 (B.coagulans BC99) in preventing RIII. C57BL/6J mice were gavage-administered with B.coagulans BC99 for 30 days and then exposed to a single dose of 12 Gy x-ray whole abdominal irradiation (WAI). B.coagulans BC99 treatment could mitigate RIII by preventing weight loss, maintaining the integrity of intestinal structure and barrier, improving inflammatory symptoms, modulating oxidative stress, and regulating the composition of gut microbiota, thereby reestablishing intestinal homeostasis. In addition, the potential radioprotective mechanism of B.coagulans BC99 was closely related to the gut microbiota-derived metabolites. This study offers a novel perspective for advancing probiotic-based treatments for RIII and enhancing strategies for the prevention of RIII.
胃肠道对电离辐射（IR）高度敏感，电离辐射会导致辐射诱导的肠道损伤（RIII）。在常规临床治疗中，尚无有效的药物可用于治疗RIII，这是盆腔腹部恶性肿瘤放射治疗过程中的一个主要限制因素。在本研究中，我们旨在阐明益生菌凝结芽孢杆菌BC99（B.coagulans BC99）在预防RIII方面的潜力。对C57BL/6J小鼠连续30天灌胃给予B.coagulans BC99，然后进行单次12 Gy X射线全腹照射（WAI）。B.coagulans BC99治疗可通过防止体重减轻、维持肠道结构和屏障的完整性、改善炎症症状、调节氧化应激以及调节肠道微生物群的组成来减轻RIII，从而重建肠道稳态。此外，B.coagulans BC99的潜在辐射防护机制与肠道微生物群衍生的代谢产物密切相关。本研究为推进基于益生菌的RIII治疗和加强RIII预防策略提供了新的视角。
