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从乳腺到眼部:尼加拉瓜一名患者发生的罕见的管腔型乳腺癌眼部转移病例

From Breast to Eye: A Rare Case of Ocular Metastasis From Luminal Breast Cancer in a Nicaraguan Patient.

作者信息

Altamirano Gilberto A, Romero Christopher, Moreno Cabrera Catherine S, Sobalvarro Johanna I, Aragón Conrado Lorenzo E

机构信息

Gynecologic Oncology, Military Teaching Hospital "Dr. Alejandro Dávila Bolaños", Managua, NIC.

School of Medicine, Military Teaching Hospital "Dr. Alejandro Dávila Bolaños", Managua, NIC.

出版信息

Cureus. 2025 Mar 17;17(3):e80748. doi: 10.7759/cureus.80748. eCollection 2025 Mar.

Abstract

Ocular metastases from breast cancer are rare but significant, with invasive lobular carcinoma (ILC) showing a higher tendency for ocular involvement than invasive ductal carcinoma (IDC). Radiotherapy is the main treatment, but the prognosis is poor. This case involves a 37-year-old woman with a history of bilateral breast cancer, initially treated with surgery, chemotherapy, and radiotherapy. She later developed pulmonary progression, bone metastases, and other complications. The patient experienced worsening vision loss, headaches, tinnitus, and systemic decline. Imaging showed brain lesions and choroidal metastasis. Extensive metastasis was confirmed, including in the pleura, liver, and bones. Ophthalmologic evaluation revealed increased intraocular pressure, requiring medical management and planned cyclophotocoagulation. Due to the advanced disease, a palliative care approach was initiated, with radiotherapy planned for ocular metastasis. This case highlights the aggressive nature of metastatic luminal B breast cancer with ocular involvement and underscores the importance of early detection and a multidisciplinary approach to patient care.

摘要

乳腺癌的眼转移罕见但严重,其中浸润性小叶癌(ILC)比浸润性导管癌(IDC)有更高的眼部受累倾向。放射治疗是主要治疗方法,但预后较差。该病例为一名37岁有双侧乳腺癌病史的女性,最初接受了手术、化疗和放疗。她后来出现肺部进展、骨转移及其他并发症。患者视力下降、头痛、耳鸣加重,全身状况恶化。影像学检查显示脑部病变和脉络膜转移。证实有广泛转移,包括胸膜、肝脏和骨骼。眼科评估显示眼压升高,需要药物治疗并计划进行睫状体光凝术。由于疾病晚期,启动了姑息治疗方案,并计划对眼部转移灶进行放射治疗。该病例突出了伴有眼部受累的转移性管腔B型乳腺癌的侵袭性,并强调了早期检测和多学科患者护理方法的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c361/12004030/527e93906f53/cureus-0017-00000080748-i01.jpg

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