肌苷-5'-单磷酸脱氢酶2（IMPDH2）在细胞生长和疾病中的核心作用：一个潜在的治疗靶点。

IMPDH2's Central Role in Cellular Growth and Diseases: A Potential Therapeutic Target.

作者信息

Li Zheng, Zou Yunpeng, Niu Jiayao, Zhang Ying, Yang Aohua, Lin Wenyu, Guo Jie, Wang Shuya, Liu Ronghan

机构信息

Central Hospital Affiliated to Shandong First Medical University, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China.

School of Clinical Medicine, Shandong Second Medical University, Weifang, China.

出版信息

Cell Prolif. 2025 Jun;58(6):e70031. doi: 10.1111/cpr.70031. Epub 2025 Apr 19.

DOI:10.1111/cpr.70031

PMID:40251939

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12179559/

Abstract

IMPDH2 is a rate-limiting enzyme in guanine nucleotide biosynthesis. It plays diverse roles in various physiological and pathological processes: nucleotide metabolism, inflammation, immune function, ribosomal stress. Structural or regulatory alterations in IMPDH2 are linked to significant health issues, and critical relevance in disease progression. We aim to underscore the potential of IMPDH2 as a promising therapeutic target for clinical applications.

摘要

肌苷-5'-单磷酸脱氢酶2（IMPDH2）是鸟嘌呤核苷酸生物合成中的一种限速酶。它在各种生理和病理过程中发挥着多种作用：核苷酸代谢、炎症、免疫功能、核糖体应激。IMPDH2的结构或调节改变与重大健康问题相关，并且在疾病进展中具有关键意义。我们旨在强调IMPDH2作为一种有前景的临床应用治疗靶点的潜力。