Improved antibacterial activity of a sustained-release biocompatible nanofilm for treating wound infection and .

OBJECTIVES

The primary goal of this research was to design a useful and biocompatible nanofilm system (CNF) encapsulating chlorhexidine acetate (CHX) for wounds that is endowed with antibacterial and anti-inflammatory activities and promotes wound healing.

METHODS

The nanofilm system was developed on the basis of the successful preparation of its nanoemulsion and PVA-CS film system and then important properties of the nanofilm system, including its morphological and physicochemical characteristics, stability and safety, its antimicrobial efficacy against was also evaluated and . The antibacterial effect, wound healing effect and inflammatory factor change were evaluated.

RESULTS

These results of this nanofilm system revealed a good particle size (59.27 nm) and stable zeta potential (-15.2 mV) that are suitable for wound healing applications. Additionally, it was stable, exhibited long-term stability (24 months) and sustained release in simulated wound fluid. Results showed that this nanofilm does not induce dose-related toxic effects and displays a better antibacterial effect that occurs more quickly, two times greater than that of CHX . This safe nanofilm enhances antibacterial activity against for 14 days, modulates the immune response, and accelerates skin wound healing .

CONCLUSIONS

These insights into multifunctional nanofilm designs for improved antibacterial effects and sustained release suggest promising clinical applications.