肠道类器官的进展与应用：模拟肠道疾病及治疗开发
Advances and applications of gut organoids: modeling intestinal diseases and therapeutic development.
作者信息
Xu Xiaoting, Zhang Yuping, Huang Guoxin, Perekatt Ansu, Wang Yan, Chen Lei
机构信息
School of Life Science and Technology, Key Laboratory of Developmental Genes and Human Disease, Southeast University, Nanjing 210031, China.
Clinical Research Center, Shantou Key Laboratory of Basic and Translational Research of Malignant Tumor, Shantou Central Hospital, Shantou 515041, China.
出版信息
Life Med. 2025 Mar 7;4(2):lnaf012. doi: 10.1093/lifemedi/lnaf012. eCollection 2025 Apr.
Gut organoids are 3D cellular structures derived from adult or pluripotent stem cells, capable of closely replicating the physiological properties of the gut. These organoids serve as powerful tools for studying gut development and modeling the pathogenesis of intestinal diseases. This review provides an in-depth exploration of technological advancements and applications of gut organoids, with a focus on their construction methods. Additionally, the potential applications of gut organoids in disease modeling, microenvironmental simulation, and personalized medicine are summarized. This review aims to offer perspectives and directions for understanding the mechanisms of intestinal health and disease as well as for developing innovative therapeutic strategies.
肠道类器官是源自成体或多能干细胞的三维细胞结构，能够紧密复制肠道的生理特性。这些类器官是研究肠道发育和模拟肠道疾病发病机制的有力工具。本综述深入探讨了肠道类器官的技术进展和应用，重点关注其构建方法。此外，还总结了肠道类器官在疾病建模、微环境模拟和个性化医学中的潜在应用。本综述旨在为理解肠道健康和疾病机制以及开发创新治疗策略提供观点和方向。
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