Hasbek Mürşit, Kıymaz Yasemin Çakır, Büyüktuna Seyit Ali, Yavuz Hayrettin
Department of Medical Microbiology, Faculty of Medicine, Sivas Cumhuriyet University, Sivas 58000, Turkey.
Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Sivas Cumhuriyet University, Sivas 58000, Turkey.
Trop Med Infect Dis. 2025 Apr 8;10(4):99. doi: 10.3390/tropicalmed10040099.
Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne zoonotic disease, causing clinical presentations ranging from asymptomatic infection to fatal viral hemorrhagic fever. Throughout the course of CCHF, the levels of certain biomarkers, such as platelets (PLTs), white blood cells (WBCs), C-reactive protein (CRP), and interleukin-6 (IL-6), may vary, decreasing below or rising above normal limits. This study aimed to investigate the role of parameters such as WBC/PLT, WBC/IL-6, WBC/CRP, and WBC/D-dimer ratios in predicting disease prognosis in patients diagnosed with CCHF. The study population consisted of 60 CCHF patients and 30 controls. Statistically significant differences were observed in hemoglobin (HGB), PLT, WBC, activated partial thromboplastin time (aPTT), international normalized ratio (INR), fibrinogen, and d-dimer values between the patients and controls. Statistically significant differences were observed in WBC/aPTT, WBC/fibrinogen, WBC/D-dimer, and WBC/IL-6 values between the patient and control groups. WBC/INR and WBC/fibrinogen values were lower in fatal cases compared to survivors. WBC/D-dimer and WBC/IL-6 values, on the other hand, were higher in fatal cases compared to survivors. In patients requiring intensive care unit (ICU), WBC/PLT, WBC/INR, WBC/aPTT, and WBC/fibrinogen values were higher compared to those who did not. However, WBC/D-dimer and WBC/IL-6 values were lower in patients requiring ICU compared to those who did not.
克里米亚-刚果出血热（CCHF）是一种由蜱传播的人畜共患病，其临床表现从无症状感染到致命的病毒性出血热不等。在CCHF病程中，某些生物标志物的水平，如血小板（PLT）、白细胞（WBC）、C反应蛋白（CRP）和白细胞介素-6（IL-6），可能会发生变化，降至正常范围以下或升至正常范围以上。本研究旨在探讨白细胞/血小板（WBC/PLT）、白细胞/白细胞介素-6（WBC/IL-6）、白细胞/ C反应蛋白（WBC/CRP）和白细胞/D-二聚体比值等参数在预测CCHF诊断患者疾病预后中的作用。研究人群包括60例CCHF患者和30例对照。患者和对照之间在血红蛋白（HGB）、PLT、WBC、活化部分凝血活酶时间（aPTT）、国际标准化比值（INR）、纤维蛋白原和D-二聚体值方面观察到统计学上的显著差异。患者组和对照组之间在白细胞/aPTT、白细胞/纤维蛋白原、白细胞/D-二聚体和白细胞/IL-6值方面观察到统计学上的显著差异。与幸存者相比，致命病例中的白细胞/INR和白细胞/纤维蛋白原值较低。另一方面，与幸存者相比，致命病例中的白细胞/D-二聚体和白细胞/IL-6值较高。在需要重症监护病房（ICU）的患者中，白细胞/PLT、白细胞/INR、白细胞/aPTT和白细胞/纤维蛋白原值高于不需要的患者。然而，与不需要ICU的患者相比，需要ICU的患者中的白细胞/D-二聚体和白细胞/IL-6值较低。
